法舒地尔与尼莫地平在颅内宽颈动脉瘤破裂弹簧圈栓塞术后患者中的应用效果比较  

Comparison of effects of Fasudil and Nimodipine on patients with intracranial wide-necked aneurysm rupture after coil embolization

作　　者：苗统 周国平[1] 王飞[1] 翟书鹏 魏康康 MIAO Tong;ZHOU Guoping;WANG Fei;ZHAI Shupeng;WEI Kangkang(2^(nd)Ward of Department of Neurosurgery of Nanyang Central Hospital,Nanyang 473000 Henan,China)

机构地区：[1]南阳市中心医院神经外科二病区,河南南阳473000

出　　处：《中国民康医学》2024年第13期142-144,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:比较法舒地尔与尼莫地平在颅内宽颈动脉瘤破裂弹簧圈栓塞术后患者中的应用效果。方法:选取2021年1月至2023年3月该院收治的80例颅内宽颈动脉瘤破裂患者进行前瞻性研究,按照随机数字法将其分为对照组和研究组各40例。两组均接受支架辅助弹簧圈栓塞术治疗,在此基础上,对照组采用尼莫地平注射液治疗,研究组采用盐酸法舒地尔注射液治疗。比较两组预后情况[改良Rankin量表(mRS)]、治疗前后神经功能缺损程度[美国国立卫生研究院卒中量表(NIHSS)]评分、脑血管痉挛发生率及不良反应发生率。结果:研究组mRS、NIHSS评分均低于对照组,差异有统计学意义(P<0.05);研究组脑血管痉挛发生率为0,低于对照组的15.00%(7/40),差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:法舒地尔用于颅内宽颈动脉瘤破裂弹簧圈栓塞术后患者可有效降低脑血管痉挛发生率,减轻患者神经功能缺损,改善预后,效果优于尼莫地平。Objective:To compare effects of Fasudil and Nimodipine on patients with intracranial wide-necked aneurysm rupture after coil embolization.Methods:A prospective study was conducted on 80 patients with ruptured intracranial wide-necked aneurysms admitted to the hospital from January 2021 to March 2023.According to the random number method,they were divided into control group and study group,40 cases in each group.Both groups were treated with stent-assisted coil embolization.On this basis,the control group was treated with Nimodipine injection,while the study group was treated with Fasudil hydrochloride injection.The prognosis[modified Rankin scale(mRS)],the degree of neurological deficit before and after the treatment[National Institutes of Health stroke scale(NIHSS)],the incidence of cerebral vasospasm,and the incidence of adverse reactions were compared between the two groups.Results:The mRS and NIHSS scores of the study group were lower than those of the control group,and the differences were statistically significant(P<0.05).The incidence of cerebral vasospasm in the study group was 0,which was lower than 15.00%(7/40)in the control group,and the difference was statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Fasudil used in the patients with intracranial wide-necked aneurysm rupture after coil embolization can effectively reduce the incidence of cerebral vasospasm,reduce the neurological deficits,and improve the prognosis.Moreover,it is superior to Nimodipine treatment.

关 键 词：颅内动脉瘤 破裂 法舒地尔 尼莫地平 支架辅助弹簧圈栓塞术 脑血管痉挛 神经功能 

分 类 号：R651.12[医药卫生—外科学]