自拟活血化瘀利水方联合超声波疗法治疗急性踝关节扭伤患者临床研究  

Treatment of acute ankle sprain patients with self-made formula for promoting blood circulation,remov-ing blood stasis,and promoting diuresis combined with ultrasound therapy

作　　者：蒋媛 占道伟 张泽元 陈忠强 汤明昊 Jiang Yuan;Zhan Daowei;Zhang Zeyuan;Chen Zhongqiang;Tang Minghao(Department of Rehabilitation Medicine,Jiaxing Traditional Chinese Medicine Hospital,Jiaxing,Zhejiang 314000,China;Department of Anesthesiology,First People′s Hospital of Jiashan,Jiashan,Zhejiang 314100,China)

机构地区：[1]嘉兴市中医医院康复医学科,浙江嘉兴314000 [2]嘉善县第一人民医院麻醉科,浙江嘉兴314100

出　　处：《中国药物与临床》2024年第9期558-562,共5页Chinese Remedies & Clinics

基　　金：浙江省嘉兴市科技计划项目(2019AD32051)。

摘　　要：目的探讨对急性踝关节扭伤患者给予自拟活血化瘀利水方联合超声波疗法对其肿胀疼痛以及炎症因子的影响。方法选取嘉兴市中医医院康复医学科2021年9月至2023年6月期间收治的86例急性踝关节扭伤患者,按随机数字表法将其分为对照组(43例)和观察组(43例),最终完成治疗的例数为82例(对照组40例,观察组42例)。对照组给予超声波治疗,观察组在对照组基础上联合自拟活血化瘀利水方治疗。比较2组患者临床疗效、治疗前后视觉模拟疼痛评分(visual analogue scale,VAS)和踝关节功能评分、肿胀情况以及血清炎症因子及氧化应激因子水平[肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、超敏C反应蛋白(high sensitivity C-reactive protein,hs-CRP)、丙二醛(malonaldehyde,MDA)、超氧化物歧化酶(su-peroxide dismutase,SOD)]。结果治疗后观察组临床总有效率、踝关节功能评分、SOD水平均明显高于对照组[95%,74%,χ^(2)=7.340,P=0.007;(142.58±5.24)分,(120.67±4.82)分,t=4.183,P=0.012;(49.69±3.15)U/mg,(47.48±3.01)U/mg,t=9.402,P<0.001];治疗后,观察组VAS评分、肿胀度、TNF-α、hs-CRP、MDA均明显低于对照组[(3.20±0.53)分,(4.81±0.63)分,t=4.360,P=0.010;(4.73±3.47)mm,(6.87±3.68)mm,t=6.482,P=0.008;(48.19±6.24)mg/L,(55.69±6.48)mg/L,t=8.523,P=0.002;(6.71±1.27)mg/L,(8.96±1.47)mg/L,t=7.206,P=0.005;(2.06±0.48)μmol/L,(3.26±0.59)μmol/L,t=9.563,P<0.001]。结论自拟活血化瘀利水方联合超声波疗法治疗急性踝关节扭伤患者疗效确切,能够有效缓解其疼痛、肿胀等症状,对改善患者踝关节功能和减轻炎症反应有一定的作用,具有临床推广价值。Objective To explore the effects of self-formulated blood activating,stasis resolving,and diuretic formula combined with ultrasound therapy on swelling,pain,and inflammatory factors in patients with acute ankle sprain.Methods A total of 86 patients with acute ankle sprains admitted to the Rehabilitation Medicine Department of Jiaxing Traditional Chinese Medicine Hospital from September 2021 to June 2023 were randomly divided into a control group(n=43)and an observation group(n=43)via a random number table method.The final number of patients who completed treatment was 82(40 cases in the control group and 42 cases in the observation group).The control group received ultrasound treatment,while the observation group received treatment in combination with a self-designed formula for promoting blood circulation,removing blood stasis,and promoting diuresis on the basis of the control group.The clinical efficacy,visual analogue pain scale(VAS)and ankle joint function score of two groups of patients before and after treatment,swelling status,and serum levels of inflammatory and oxidative stress factors[Tumor Necrosis Factor alpha,TNF-α),high sensitivity C-reactive protein(hs-CRP),malonaldehyde(MDA),Superoxide dismutase(SOD)].Results After treatment,the total clinical effective rate,ankle joint function score,and SOD level in the observation group were significantly higher than those in the control group[95.35%,74.42%],χ^(2)=7.340,P=0.007;(142.58±5.24)points,(120.67±4.82)points,t=4.183,P=0.012;(49.69±3.15)U/mg,(47.48±3.01)U/mg,t=9.402,P<0.001];After treatment,VAS score,swelling degree,and TNF-α,hs CRP and MDA in the observation group were significantly lower than those in the control group[(3.20±0.53)points,(4.81±0.63)points,t=4.360,P=0.010;(4.73±3.47)mm,(6.87±3.68)mm,t=6.482,P=0.008;(48.19±6.24)mg/L,(55.69±6.48)mg/L,t=8.523,P=0.002;(6.71±1.27)mg/L,(8.96±1.47)mg/L,t=7.206,P=0.005;(2.06±0.48)μmol/L,(3.26±0.59)μmol/L,t=9.563,P<0.001].Conclusion The self-made formula for activating blood circulation,removi

关 键 词：踝损伤 自拟活血化瘀利水方 超声波 血清炎症因子 踝关节功能 

分 类 号：R274[医药卫生—中医骨伤科学]