西藏门巴族人群胰岛细胞功能、脂质代谢、炎症反应与中医体质的相关性研究  

Study on the correlation between the function of islet cells,lipid metabolism,inflammatory reaction and the constitution of traditional Chinese medicine in Tibetan Menba people

作　　者：劳美铃[1] 魏爱生[1] 何芬 黄中梁 王文会[4] 邓声敏 杨东山 张珏 阿旺仓决 郭燕 Lao Mei-ling;Wei Ai-sheng;He Fen;Huang Zhong-liang;Wang Wen-hui;Deng Sheng-min;Yang Dong-shan;Zhang Jue;Awang Cangjue;Guo yan(Department of Endocrinology,Foshan Traditional Chinese Medicine Hospital,Fosan,Guangdong 528000,China;Department of Rehabilitation Medicine,Foshan Traditional Chinese Medicine Hospital,Fosan,Guangdong 528000,China;Department of Acupuncture and moxibustion,Foshan Traditional Chinese Medicine Hospital,Fosan,Guangdong 528000,China;Department of Cardiology,Foshan Traditional Chinese Medicine Hospital,Fosan,Guangdong 528000,China;Department of Internal Medicine,People's Hospital of Mêdog County,Xizang Autonomous Region 860700,China;Department of Preventive Medicine,Mêdog County Xizang Hospital,Mêdog County,Xizang Autonomous Region 860700,China;Department of Traditional Chinese Medicine,People's Hospital of Mêdog County,Xizang Autonomous Region 860700,China)

机构地区：[1]佛山市中医院内分泌科,广东佛山528000 [2]佛山市中医院康复医学科,广东佛山528000 [3]佛山市中医院针灸科,广东佛山528000 [4]佛山市中医院心内科,广东佛山528000 [5]西藏自治区墨脱县人民医院大内科,西藏墨脱县860700 [6]西藏自治区墨脱县藏医院,西藏墨脱县860700 [7]西藏自治区墨脱县人民医院中医科,西藏墨脱县860700

出　　处：《中国现代医学杂志》2024年第13期91-96,共6页China Journal of Modern Medicine

基　　金：广东省医学科学技术研究基金项目(No:B2021340);佛山市自筹经费类科技创新项目(No:2220001004601);佛山市科技创新项目自筹经费类科技计划项目(No:2020001005589)。

摘　　要：目的探讨西藏门巴族人群胰岛细胞功能、脂质代谢和炎症反应与中医体质的相关性。方法选取2023年1月—2023年6月墨脱村、亚东村、朗杰岗村、巴日村、德吉村、玛迪村6个门巴族乡的门巴族人群进行调查,共计237例。分析人群中医体质分布情况,同时比较前三位中医体质人群的胰岛细胞功能、脂质代谢和炎症因子水平。结果中医体质类型中以痰湿质、湿热质和气虚质为主,分别占32.07%、26.16%和18.57%。痰湿质组、湿热质组和气虚质组性别、年龄、体质量指数比较,差异均无统计学意义(P>0.05)。湿热质组空腹血糖和胰岛素抵抗指数分别为(4.98±0.83)mmol/L和(1.75±0.32),均低于痰湿质组和气虚质组(P<0.05),湿热质组胰岛β细胞功能指数为(94.45±9.11),均高于痰湿质和气虚质组(P<0.05);湿热质组总胆固醇和甘油三酯分别为(3.98±0.99)mmol/L和(1.02±0.29)mmol/L,均低于痰湿质组和气虚质组(P<0.05),湿热质组高密度脂蛋白胆固醇为(1.26±0.20)mmol/L,均高于痰湿质组和气虚质组(P<0.05)。痰湿质、湿热质和气虚质组血清白细胞介素-6、超敏c反应蛋白、肿瘤坏死因子-α比较,差异均无统计学意义(P>0.05)。结论西藏门巴族人群中医体质以痰湿质、湿热质和气虚质为主,其中湿热质人群胰岛细胞功能、脂质代谢优于痰湿质和气虚质人群,炎症因子比较无差异。Objective To explore the correlation between islet cell function,lipid metabolism,inflammatory response,and traditional Chinese medicine(TCM)constitution in the Xizang Menba ethnic group.Methods From Januaryto June 2023,a total of 237 people were selected from 6 Menba villages,including Motuo Village,Yadong Village,Langjie Gang Village,Bari Village,Deji Village and Madi Village.The distribution of TCM constitution of the population were analyzed,and the top three people of Chinese medicine constitution were selected to compare the differences in islet cell function,lipid metabolism and inflammatory factor level and so on.Results The main types of TCM constitution arephlegm-dampness,damp-heat and qi-deficiency,accounting for 32.07%,26.16%and 18.57%respectively.There was no significant difference in sex,age and body mass index between the phlegm-dampness,damp-heat and qi-deficiency groups(P>0.05).The fasting blood glucose and insulin resistance index(HOMA-IR)in the damp-heat group were(4.98±0.83)mmol/L and(1.75±0.32),respectively,which were significantly lower than those in the phlegm-dampnessand qi-deficiency groups(P<0.05),while HOMA-βwas(94.45±9.11),which was higher than those in the phlegm-dampnessand qi-deficiency groups(P<0.05).The total cholesterol(TC)and triglyceride(TG)in the damp-heatgroup were(3.98±0.99)mmol/L and(1.02±0.29)mmol/L,respectively,which were lower than those in the group of phlegm-dampnessand qi-deficiency(P<0.05),while high-density lipoprotein cholesterol(HDL-C)was(1.26±0.20)mmol/L,which was higher than that of thephlegm-dampnessand qi-deficiencygroups(P<0.05).There was no statistically significant difference in serum interleukin-6(IL-6),C-reactive protein(CRP)and tumor necrosis factor-α(TNF-α)among the phlegm-dampness,damp-heat and qi-deficiency groups(P>0.05).Conclusion The traditional Chinese medicine constitution of Xizang Menba people is dominated by phlegm-dampness,damp-heat and qi-deficiency.Among them,the function of islet cells and lipid metabolism of damp-heat people are

关 键 词：胰岛细胞功能 脂质代谢 炎症反应 中医体质 西藏门巴族 

分 类 号：R587.1[医药卫生—内分泌]