银屑病患者真菌分布特点及萘替芬酮康唑乳膏辅助治疗的应用效果  

Fungal Distribution Characteristics of Patients with Psoriasis and the Application Effect of Naftifine Hydrochloride and Ketoconazole Cream in Adjuvant Therapy

作　　者：刘海兵 LIU Haibing(Jianli Traditional Chinese Medicine Hospital,Jianli 433300,China)

机构地区：[1]监利市中医医院,湖北监利433300

出　　处：《中外医学研究》2024年第16期170-174,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:分析银屑病患者真菌分布特点及萘替芬酮康唑乳膏辅助治疗效果。方法:选取2022年1月—2023年5月监利市中医医院皮肤科收治的120例银屑病患者。根据随机数表法将其分为研究组与对照组,各60例。对照组给予卤米松乳膏,研究组在对照组基础上给予萘替芬酮康唑乳膏。分析所有患者真菌分布情况。比较两组临床疗效,治疗前、治疗4周后皮损情况及瘙痒程度、炎症因子及不良反应。结果:120例银屑病患者中,共检出病原菌141株,真菌37株(26.24%),其中球形马拉色菌16株(43.24%),限制性马拉色菌10株(27.03%),酵母菌4株(10.81%),皮肤癣菌4株(10.81%),其他3株(8.11%)。治疗4周后,研究组总有效率(86.67%)明显高于对照组(71.67%),差异有统计学意义(P<0.05)。治疗4周后,两组银屑病皮损面积及严重程度指数(PASI)、视觉模拟评分法(VAS)评分均明显低于治疗前,研究组PASI评分、VAS评分均明显低于对照组,差异有统计学意义(P<0.05)。治疗4周后,两组白细胞介素-17(IL-17)、肿瘤坏死因子-α(TNF-α)及γ干扰素(IFN-γ)水平均降低,研究组IL-17、IFN-γ和TNF-α水平均低于对照组,差异有统计学意义(P<0.05)。两组治疗期间均未出现刺激性疼痛、皮肤过敏等严重不良反应。结论:银屑病患者真菌以球形/限制性马拉色菌为主,在卤米松乳膏基础上加用萘替芬酮康唑乳膏辅助治疗,能取得更佳效果,可以让炎症因子水平下降,同时没有增加不良反应。Objective:To analyze the fungal distribution characteristics of patients with psoriasis and the application effect of Naftifine Hydrochloride and Ketoconazole Cream in adjuvant therapy.Method:A total of 120 patients with psoriasis admitted to the Dermatology Department of Jianli Traditional Chinese Medicine Hospital from January 2022 to May 2023 were selected.According to random number table method,the patients were divided into study group and control group,60 cases in each group.The control group was given Halometasone Cream,and the study group was given Naftifine Hydrochloride and Ketoconazole Cream on the basis of the control group.The fungal distribution of all patients was analyzed.The clinical efficacy,and the skin lesions condition and itching degree,inflammatory factors before treatment and after 4 weeks of treatment and adverse reactions of the two groups were compared.Result:Among 120 psoriasis patients,141 strains of pathogenic bacteria and 37 strains fungi(26.24%)were detected,including 16 strains Malassezia Spherosa(43.24%),10 strains Malassezia Restricta(27.03%),4 yeast strains(10.81%),4 dermatophyte strains(10.81%),and 3 other strains(8.11%).After 4 weeks of treatment,the total effective rate of the study group(86.67%)was significantly higher than that of the control group(71.67%),and the difference was statistically significant(P<0.05).After 4 weeks of treatment,the psoriasis area and severity index(PASI)and visual analog scale(VAS)scores of the two groups were significantly lower than those before treatment,and the PASI and VAS scores of the study group were significantly lower than those of the control group,and the differences were statistically significant(P<0.05).After 4 weeks of treatment,the levels of interleukin-17(IL-17),tumor necrosis factor-α(TNF-α)and interferon-γ(IFN-γ)in both groups were decreased,and the levels of IL-17,IFN-γand TNF-αin the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).During the treatment pe

关 键 词：银屑病 真菌 分布特点 萘替芬酮康唑乳膏 疗效 炎症因子 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]