T淋巴细胞免疫在COPD肺气肿发病机制中的作用  

Role of T Lymphocyte Immunity in the Pathogenesis of COPD Emphysema

作　　者：王亮亮 宋春雪 丁琦 魏霞 WANG Liangliang;SONG Chunxue;DING Qi;WEI Xia(Xi’an Medical University,Xi’an 710021,China;不详)

机构地区：[1]西安医学院,陕西西安710021 [2]延安大学医学院 [3]西安市第九医院

出　　处：《中外医学研究》2024年第16期179-184,共6页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：西安市卫生健康委员会青年培育项目(2023qn10);西安市科技计划项目(21YXYJ0070)。

摘　　要：肺气肿是慢性阻塞性肺疾病(COPD)典型的病理改变,其发生发展离不开免疫炎症反应的参与。T淋巴细胞与COPD肺气肿异常免疫炎症反应的关系非常密切,CD8^(+)T和CD4^(+)T细胞的不同亚型可分泌特定细胞因子[如颗粒酶、穿孔素、γ干扰素(INF-γ)、肿瘤坏死因子-α(TNF-α)、白细胞介素-17(IL-17)等],在促进肺泡细胞凋亡、调节免疫反应和维持肺部炎症中发挥着至关重要的作用。本文综述了近年来T淋巴细胞介导的适应性免疫在COPD肺气肿发病机制中的研究进展,旨在为COPD肺气肿预防和治疗提供新思路。Emphysema is a typical pathological change of chronic obstructive pulmonary disease(COPD),and its occurrence and development cannot be separated from the participation of immune inflammation.T lymphocytes are closely related to the abnormal immunoinflammatory response of COPD emphysema.Different subtypes of CD8^(+)T and CD4^(+)T cells can secrete specific cytokines[such as granase,perforin,interferon-γ(INF-γ),tumor necrosis factor-α(TNF-α),interleukin-17(IL-17),etc.];it plays a crucial role in promoting alveolar cell apoptosis,regulating immune response and maintaining lung inflammation.This article reviews the recent progress of T lymphocyte mediated adaptive immunity in the pathogenesis of COPD emphysema,aiming to provide new ideas for the prevention and treatment of COPD emphysema.

关 键 词：慢性阻塞性肺疾病 肺气肿 T淋巴细胞 免疫炎症 

分 类 号：R563.9[医药卫生—呼吸系统]