甘露醇联合骨肽注射液治疗胫腓骨骨折术后肢体肿胀的效果  

Effect of Mannitol Combined with Bone Peptide Injection on Limb Swelling after Tibial and Fibula Fracture Surgery

作　　者：王守明 WANG Shouming(Yunmeng People's Hospital,Yunmeng 432500,China)

机构地区：[1]云梦县人民医院,湖北云梦432500

出　　处：《中外医学研究》2024年第17期129-133,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探究甘露醇联合骨肽注射液治疗胫腓骨骨折术后肢体肿胀的效果。方法:选取2022年1月—2023年1月于云梦县人民医院进行胫腓骨骨折手术的80例患者作为研究对象,利用随机数表法将其分为对照组和观察组,各40例。两组术后均给予常规治疗,对照组采用甘露醇治疗,观察组在对照组基础上联合骨肽注射液治疗。比较两组临床疗效、肢体肿胀程度、疼痛程度、血液流变学指标及肢体肿胀消失时间。结果:观察组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组肢体肿胀程度、疼痛程度、血液流变学指标比较,差异无统计学意义(P>0.05)。治疗后,观察组肢体肿胀程度轻于对照组,差异有统计学意义(P<0.05);治疗后,两组视觉模拟评分法(VAS)评分、全血高切黏度、全血低切黏度、血浆黏度均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组肢体肿胀消退时间早于对照组,差异有统计学意义(P<0.05)。结论:甘露醇联合骨肽注射液可以改变胫腓骨骨折术后肢体肿胀患者的血流动力学指标,减轻患者的疼痛程度和肢体肿胀程度,促进患者肿胀症状消退,提高临床疗效。Objective:To explore the effect of Mannitol combined with Bone Peptide Injection on limb swelling after tibial and fibula fracture surgery.Method:A total of 80 patients who underwent tibia and fibula fracture surgery in Yunmeng People's Hospital from January 2022 to January 2023 were selected as the study objects,and they were divided into control group and observation group by random number table method,with 40 patients in each group.Both groups were given routine treatment after operation,the control group was treated with Mannitol,and the observation group was treated with Bone Peptide Injection on the basis of the control group.The clinical effect,limb swelling degree,pain degree,hemorheology indexes and the time of limb swelling resolution were compared between the two groups.Result:The total effective rate of the observation group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in the limb swelling degree,pain degree and hemorheology indexes between the two groups(P>0.05).After treatment,the limb swelling degree in the observation group was less than that in the control group,the difference was statistically significant(P<0.05).After treatment,visual analogue scale(VAS)score,whole blood high shear viscosity,whole blood low shear viscosity and plasma viscosity in two groups were lower than those before treatment,and which in observation group were lower than those in control group,the differences were statistically significant(P<0.05).The time of limb swelling regression in the observation group was earlier than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:Mannitol combined with Bone Peptide Injection can change the hemorheology indexes of patients with limb swelling after tibia and fibula fracture,reduce the degree of pain and limb swelling,promote the regression of swelling symptoms in patients,and improve clinical efficacy.

关 键 词：骨肽注射液 甘露醇 胫腓骨骨折 肢体肿胀 血流动力学 

分 类 号：R687.3[医药卫生—骨科学]