瑞芬太尼复合麻醉对结肠癌根治术患者的影响  

Effect of Remifentanil Compound Anesthesia on Patients Undergoing Colon Cancer Radical Operation

作　　者：林沈娴 陈欢 陈海 LIN Shenxian;CHEN Huan;CHEN Hai(The First Hospital of Putian City,Putian 351100,China)

机构地区：[1]莆田市第一医院,福建莆田351100

出　　处：《中外医学研究》2024年第18期137-141,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨瑞芬太尼复合麻醉对结肠癌根治术患者的影响。方法:选取2021年11月—2023年9月莆田市第一医院收治的96例结肠癌根治术患者。根据随机数表法将其分为对照组(48例)与研究组(48例)。对照组给予舒芬太尼复合麻醉,研究组给予瑞芬太尼复合麻醉。比较两组苏醒情况,术前、术后24 h氧化应激反应指标、免疫功能及不良反应。结果:研究组自主呼吸恢复时间、意识恢复时间、拔管时间均早于对照组,差异有统计学意义(P<0.05)。术后24 h,两组过氧化氢酶(CAT)、超氧化物歧化酶(SOD)水平降低,丙二醛(MDA)水平升高,研究组CAT、SOD水平均高于对照组,MDA水平低于对照组,差异有统计学意义(P<0.05)。术后24 h,两组CD3^(+)、CD4^(+)水平均降低,CD8水平升高,研究组CD3^(+)、CD4^(+)水平均高于对照组,CD8水平低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:瑞芬太尼复合麻醉可缩短结肠癌根治术患者苏醒时间,减轻氧化应激反应,改善免疫功能,且安全性好。Objective:To explore the effect of Remifentanil compound anesthesia on patients undergoing colon cancer radical operation.Method:A total of 96 patients with who underwent colon cancer radical operation at the First Hospital of Putian City from November 2021 to September 2023 were selected.They were divided into the control group(48 cases)and the study group(48 cases)by the random table method.The control group was given Sufentanil compound anesthesia,while the study group was given Remifentanil compound anesthesia.The recovery status,oxidative stress response indicators and immune function before and 24 h after operation,and adverse reactions between two groups were compared.Result:The spontaneous breathing recovery time,consciousness recovery time and extubation time of the study group were earlier than those of the control group,and the differences were statistically significant(P<0.05).At 24 h after operation,the levels of catalase(CAT)and superoxide dismutase(SOD)in two groups were decreased,and the levels of malondialdehyde(MDA)were increased,the levels of CAT and SOD in the study group were higher than those in the control group,and the level of MDA was lower than that in the control group,the differences were statistically significant(P<0.05).At 24 h after operation,the levels of CD3^(+)and CD4^(+)in two groups were decreased,while the levels of CD8^(+)were increased,the levels of CD3^(+)and CD4^(+)in the study group were higher than those in the control group,while the levels of CD8^(+)were lower than those in the control group,the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between two groups(P>0.05).Conclusion:Remifentanil compound anesthesia in patients undergoing colon cancer radical operation can shorten the recovery time,reduce oxidative stress reaction,improve immune function,and has good safety.

关 键 词：结肠癌根治术 瑞芬太尼 复合麻醉 苏醒时间 氧化应激反应 

分 类 号：R614[医药卫生—麻醉学] R735.35[医药卫生—外科学]