清肝利湿颗粒联合恩替卡韦治疗肝胆湿热型乙肝肝硬化的临床疗效观察  

Clinical observation of Qinggan Lishi Granules combined with Entecavir in the treatment of hepatitis B cirrhosis with hepatobiliary damp heat type

作　　者：谢燕媚 何义华 吴少麟 黄应起 XIE Yanmei;HE Yihua;WU Shaolin;HUANG Yingqi(Department of Pharmacy,Zhaoqing Traditional Chinese Medicine Hospital,Guangdong Province,Zhaoqing526020,China)

机构地区：[1]广东省肇庆市中医院药学部,广东肇庆526020

出　　处：《中国当代医药》2024年第19期26-29,共4页China Modern Medicine

基　　金：广东省肇庆市科技计划项目(2021040311018)。

摘　　要：目的探讨清肝利湿颗粒联合恩替卡韦治疗肝胆湿热型乙型肝炎(以下简称“乙肝”)肝硬化的临床效果。方法选取2021年1月至2023年4月肇庆市中医院收治的100例肝胆湿热型乙肝肝硬化患者作为研究对象,按照随机抽签的方式分为对照组(50例)和研究组(50例)。对照组采用恩替卡韦治疗,研究组采用恩替卡韦与清肝利湿颗粒联合治疗。比较两组患者临床疗效、生化指标(丙氨酸转氨酶、天冬氨酸转氨酶、总胆红素)、影像学特征、乙肝病毒DNA转阴率以及不良反应发生情况。结果研究组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,研究组患者丙氨酸转氨酶、天冬氨酸转氨酶、总胆红素水平均低于对照组,差异有统计学意义(P<0.05)。治疗后,研究组患者门静脉内径、门静脉最大流速、脾静脉内径、脾静脉最大流速均低于对照组,差异有统计学意义(P<0.05)。研究组乙肝病毒DNA转阴率高于对照组,差异有统计学意义(P<0.05)。研究组发生4例不良反应,对照组发生6例不良反应,两组患者不良反应总发生率比较,差异无统计学意义(P>0.05)。结论清肝利湿颗粒联合恩替卡韦治疗肝胆湿热型乙肝肝硬化的效果显著,可有效抑制乙型肝炎病毒复制,改善患者肝功能,且安全性较高。Objective To investigate the clinical effect of Qinggan Lishhi Granules combined with Entecavir in the treatment of hepatobiliary damp heat type hepatitis B cirrhosis.Methods A total of 100 patients with hepatobiliary damp heat type hepatitis B cirrhosis treated in Zhaoqing Hospital of Traditional Chinese Medicine from January 2021 to April 2023 were selected as the study objects,and divided into control group(50 cases)and study group(50 cases)according to random drawing method.The control group was treated with Entecavir,and the study group was treated with Entecavir combined with Qinggan Lishi Granules.The clinical efficacy,biochemical indexes(alanine aminotransferase,aspartate aminotransferase,total bilirubin),imaging features,hepatitis B virus DNA negative conversion rate and adverse reactions were compared between the two groups.Results The total effective rate of the study group was higher than that of the control group,the difference was statistically significant(P<0.05).After treatment,the levels of alanine transaminase,aspartate transaminase and total bilirubin in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the internal diameter of the portal vein,the maximum velocity of the portal vein,the internal diameter of the splenic vein and the maximum velocity of the splenic vein in the study group were lower than those in the control group,with statistical significances(P<0.05).The negative rate of hepatitis B virus DNA in the study group was higher than that in the control group,and the difference was statistically significant(P<0.05).There were 4 cases of adverse reactions in the study group and 6 cases in the control group.There was no statistical significance in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Qinggan Lishi Granules combined with Entecavir can effectively inhibit hepatitis B virus replication and improve liver function in the treatment of hepatobiliary damp heat type h

关 键 词：清肝利湿颗粒 恩替卡韦 乙型肝炎 肝硬化 肝功能 

分 类 号：R259[医药卫生—中西医结合]