清暑益气汤加减治疗艾滋病合并肺孢子菌肺炎气阴两虚兼痰热证临床研究  

Clinical study on modified Qingshu Yiqi Decoction in the treatment of acquired immune deficiency syndrome complicated with pneumocystis pneumonia with qi-yin deficiency and phlegm heat syndrome

作　　者：刘明山 胡典贵 黄伟霞 吴靖 周刚峰 LIU Mingshan;HU Diangui;HUANG Weixia;WU Jing;ZHOU Gangfeng(Department of Traditional Chinese Medicine,the Fifth People's Hospital of Ganzhou,Jiangxi Province,Ganzhou341000,China;Department of Infectious Diseases,the Fifth People's Hospital of Ganzhou,Jiangxi Province,Ganzhou341000,China)

机构地区：[1]江西省赣州市第五人民医院中医科,江西赣州341000 [2]江西省赣州市第五人民医院感染科,江西赣州341000

出　　处：《中国当代医药》2024年第19期91-94,共4页China Modern Medicine

基　　金：江西省中医药管理局科技计划项目(2022B886)。

摘　　要：目的探究清暑益气汤加减治疗艾滋病(AIDS)合并肺孢子菌肺炎(PCP)气阴两虚兼痰热证的临床效果。方法选取2022年1月至2023年10月赣州市第五人民医院收治的60例AIDS合并PCP患者为研究对象,采用随机数字表法分为治疗组和对照组,各30例。对照组采用常规西医治疗,在此基础上,治疗组采用清暑益气汤加减治疗。比较两组患者的临床疗效、中医证候积分、实验室指标、血气指标及安全性。结果治疗组的临床总有效率高于对照组,差异有统计学意义(P<0.05);治疗后,治疗组的中医证候积分低于对照组,差异有统计学意义(P<0.05);治疗组T淋巴细胞计数(CD4+)、白蛋白(ALB)水平高于对照组,差异有统计学意义(P<0.05);治疗组白细胞计数(WBC)、乳酸脱氢酶(LDH)水平低于对照组,差异有统计学意义(P<0.05);治疗组血氧饱和度(SaO_(2))水平高于对照组,动脉氧分压(PaO_(2))、动脉二氧化碳分压(PaCO_(2))水平低于对照组,差异有统计学意义(P<0.05);治疗组不良事件总发生率低于对照组,差异有统计学意义(P<0.05)。结论对气阴两虚兼痰热证型的AIDS合并PCP患者进行清暑益气汤加减治疗能有效提高治疗效果,减轻症状,改善血气指标,提高血氧饱和度,减少不良事件发生情况。Objective To investigate the clinical effect of modified Qingshu Yiqi decoction in the treatment of acquired immune deficiency syndrome(AIDS)complicated with pneumocystis pneumonia(PCP)with qi-yin deficiency and phlegm heat syndrome.Methods Sixty patients with AIDS combined with PCP admitted to the Fifth People's Hospital of Ganzhou from January 2022 to October 2023 were selected as the study objects,and they were divided into treatment group and control group by random number table method,with 30 cases in each group.The control group was treated with conventional western medicine,on this basis,the treatment group was treated with Qingshu Yiqi Decoction.Clinical efficacy,traditional Chinese medicine syndrome scores,laboratory indicators,blood gas indicators,and safety were compared between the two groups.Results The total clinical effective rate of the treatment group was higher than that of the control group,the difference was statistically significant(P<0.05).After treatment,traditional Chinese medicine syndrome scores of the treatment group were lower than those of the control group,with statistically significant differences(P<0.05).T lymphocyte count(CD4+)and albumin(ALB)level of the treatment group were higher than those of the control group,with statistically significant differences(P<0.05).White blood cell count(WBC)and lactate dehydrogenase(LDH)level were lower than those of the control group,with statistically significant differences(P<0.05).Blood oxygen saturation(SaO_(2))of the treatment group was higher than that of the control group,arterial partial pressure of oxygen(PaO_(2))and arterial partial pressure of carbon dioxide(PaCO_(2))were lower than those of the control group,with statistically significant differences(P<0.05).The total incidence of adverse events in the treatment group was lower than that in the control group,with statistically significant difference(P<0.05).Conclusion Applying modified Qingshu Yiqi decoction to treat AIDS patients with PCP of qi-yin deficiency and phlegm heat syndrome

关 键 词：艾滋病 肺孢子菌肺炎 气阴两虚 清暑益气汤 

分 类 号：R512.91[医药卫生—内科学]