司库奇尤单抗和阿达木单抗治疗中重度斑块状银屑病的疗效及安全性对比  

Comparison of efficacy and safety of secukinumab and adalimumab in the treatment of moderate to severe plaque psoriasis

作　　者：李慧[1] LI Hui(Jinan Dermatology Prevention and Treatment Hospital,Jinan 250001,China)

机构地区：[1]济南市皮肤病防治院,250001

出　　处：《中国实用医药》2024年第12期124-127,共4页China Practical Medicine

摘　　要：目的 分析对比司库奇尤单抗和阿达木单抗治疗中重度斑块状银屑病的效果和安全性。方法 94例中重度斑块状银屑病患者,以随机数字表法分为对照组与研究组,各47例。对照组采用阿达木单抗进行治疗,研究组采用司库奇尤单抗进行治疗。对比两组患者的银屑病面积与严重性指数及其改善率,不良反应发生率。结果 治疗后第4、8、12周,研究组患者的银屑病面积与严重性指数分别为(7.55±6.51)、(4.60±5.85)、(2.90±5.55)分,对照组分别为(10.37±6.67)、(6.77±6.41)、(3.80±5.75)分。治疗后第4周,研究组患者的银屑病面积与严重性指数低于对照组,存在统计学意义(P<0.05)。治疗后第8、12周,两组患者的银屑病面积与严重性指数相差无统计意义(P>0.05)。对照组患者治疗后第4周的银屑病面积与严重性指数改善率为(51.13±8.69)%,第8周的银屑病面积与严重性指数改善率为(68.10±9.48)%,第12周的银屑病面积与严重性指数改善率为(82.09±9.62)%。研究组患者治疗后第4周的银屑病面积与严重性指数改善率为(66.62±9.04)%,第8周的银屑病面积与严重性指数改善率为(79.66±9.88)%,第12周的银屑病面积与严重性指数改善率为(87.17±10.30)%。研究组治疗后第4、8、12周的银屑病面积与严重性指数改善率明显高于对照组,存在统计学意义(P<0.05)。两组患者的不良反应发生率相差无统计意义(P>0.05)。结论 司库奇尤单抗和阿达木单抗对中重度斑块状银屑病均有显著疗效,不良反应的发生几率相差不大,均具有较高的安全性,可优先选择司库奇尤单抗。Objective To analyze the effect and safety of secukinumab and adalimumab in the treatment of moderate to severe plaque psoriasis.Methods 94 cases of moderate to severe plaque psoriasis patients were divided into a control group and a study group according to random number table method,with 47 cases in each group.The control group was treated with adalimumab,and the study group was treated with secukinumab.The psoriasis area and severity index,improvement rate and incidence of adverse reactions were compared between the two groups.Results At 4,8 and 12 weeks after treatment,the psoriasis area and severity index of the study group were(7.55±6.51),(4.60±5.85)and(2.90±5.55)points,and those of the control group were(10.37±6.67),(6.77±6.41)and(3.80±5.75)points.At 4 weeks after treatment,the psoriasis area and severity index of the study group were lower than that of the control group,there was statistical significance(P<0.05).At 8 and 12 weeks after treatment,the psoriasis area and severity index of the two groups were not statistically significant(P>0.05).In the control group,the improvement rate of psoriasis area and severity index at 4 weeks after treatment was(51.13±8.69)%,the improvement rate of psoriasis area and severity index at 8 weeks was(68.10±9.48)%,and the improvement rate of psoriasis area and severity index at 12 weeks was(82.09±9.62)%.In the study group,the improvement rate of psoriasis area and severity index at 4 weeks after treatment was(66.62±9.04)%,the improvement rate of psoriasis area and severity index at 8 weeks after treatment was(79.66±9.88)%,and the improvement rate of psoriasis area and severity index at 12 weeks after treatment was(87.17±10.30)%.The improvement rates of psoriasis area and severity index in the study group at 4,8 and 12 weeks after treatment were significantly higher than those in the control group,and there was statistical significance(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Bot

关 键 词：司库奇尤单抗 阿达木单抗 中重度斑块状银屑病 安全性 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]