Siglec在肝移植免疫调控机制中的研究进展  

Research progress of Siglec in immune regulatory mechanisms of liver transplantation

作　　者：罗杰夫 龚建平[1] 成名翔[1] LUO Jiefu;GONG Jianping;CHENG Mingxiang(Department of Hepatobiliary Surgery,the Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China)

机构地区：[1]重庆医科大学附属第二医院肝胆外科,重庆400010

出　　处：《重庆医学》2024年第13期2059-2064,共6页Chongqing medicine

基　　金：重庆市自然科学基金面上项目(cstc2020jcyj-msxmX0791);重庆市科卫联合医学科研项目(2023MSXM020);重庆市教育委员会科学技术研究项目(KJQN202000405)。

摘　　要：在各种免疫调节系统中,存在着一种表达于免疫细胞表面的跨膜受体,可选择性地发挥作用,即唾液酸结合免疫球蛋白样凝集素(Siglec)家族。抑制宿主T细胞抗原应答是诱导肝移植免疫耐受的关键因素,新近发现Siglec-15是重要的T细胞抑制分子,部分家族成员与其具有相似的结构及生物学特性,由此,推测Siglec家族的成员可能成为诱导肝脏免疫耐受的新靶点。该文对这一领域的相关文献进行综述,以Siglec-15为切入点,探讨Siglec家族在抑制宿主T细胞抗原应答及调控免疫反应中可能的作用和分子机制,为移植术后免疫调控和免疫耐受的建立提供新的思路。In various immunomodulatory systems,there exists a transmembrane receptor expressed on the surface of immune cells,which can play a role selectively,namely the sialic-binding immunoglobulin-like lectin(Siglec)family.Inhibition of host T cell antigen response is a key factor in inducing immune tolerance of liver transplantation.Recently,Siglec-15 has been found to be an important T cell suppressor molecule,and some of its family members have similar structure and biological characteristics.It is speculated that the members of Siglec family may be a new target for inducing liver immune tolerance.Therefore,this paper reviews the relevant literatures in this field,and takes Siglec-15 as the entry point to explore the possible role and molecular mechanism of Siglec family in inhibiting host T cell antigen response and regulating immune response in order to provide the new ideas for the establishment of immune regulation and tolerance after transplantation.

关 键 词：唾液酸结合免疫球蛋白样凝集素 肝脏移植 免疫耐受 免疫排斥 缺血再灌注 综述 

分 类 号：R392.4[医药卫生—免疫学]