冠心病并发幽门螺杆菌感染血清型和Hcy与HSP60及gastrin水平  

Serotypes,Hey,HSP60 and gastrin of coronary heart disease patients complicated with Helicobacter pylori infection

作　　者：汤诗卉 黄薇[1] 杨倩 王萌 余志华[1] TANG Shi-hui;HUANG Wei;YANG Qian;WANG Meng;YU Zhi-hua(Wuhan First Hospital,Wuhan,Hubei 430030,China)

机构地区：[1]武汉市第一医院心内科,湖北武汉430030

出　　处：《中华医院感染学杂志》2024年第11期1631-1634,共4页Chinese Journal of Nosocomiology

基　　金：湖北省自然科学基金资助项目(2022CFB966)。

摘　　要：目的探讨冠心病患者不同程度幽门螺杆菌(Hp)感染血清型血清同型半胱氨酸(Hcy)与热休克蛋白60(HSP60)及胃泌素(gastrin)水平.方法以2019年3月-2023年3月武汉市第一医院收治的冠心病患者368例作为病例组,以同期于医院进行体检的370名健康体检者作为健康对照组,统计两组临床资料、Hp感染情况及血清Hcy、HSP60、gastrin水平,比较不同Hp感染血清型、不同感染程度冠心病患者血清Hcy、HSP60、gastrin水平.结果病例组Hp感染患者占比及Ⅰ型患者占比高于健康对照组(P<0.05);病例组血清Hcy、HSP60、gastrin均高于健康对照组(P<0.05);非感染组、Ⅱ型组、Ⅰ型组血清Hcy、HSP60、gastrin水平呈逐渐升高趋势(P<0.05);重度感染组血清Hcy、HSP60、gastrin水平高于轻度感染组(P<0.05).结论冠心病患者发生Hp感染可引起血清Hcy、HSP60、gastrin水平变化,同时血清Hcy、HSP60、gastrin与冠心病合并Hp感染患者血清型、感染程度有关,有望成为预测冠心病患者Hp感染程度的标志物.OBJECTIVE To investigate the effects of serum type and degree of Helicobacter pylori(Hp)infection on serum homocysteine(Hcy),heat shock protein 60(HSP60)and gastrin(gastrin)levels in patients with coronary heart disease.METHODS A total of 368 patients with coronary heart disease admitted to Wuhan First Hospital from Mar.2019 to Mar.2023 were selected as the study group,and 370 healthy subjects who underwent physical examination in Wuhan First Hospital during the same period were selected as the healthy control group.The clinical data,status of Hp infection and levels of serum Hcy,HSP60 and gastrin of the two groups were analyzed.The serum levels of Hcy,HSP60 and gastrin in patients with coronary heart disease with different Hp infection serotypes and different infection degrees were compared.RESULTS The proportion of Hp infection and type I patients in the study group was higher than that in the healthy control group(P<0.05).Serum levels of Hcy,HSP60 and gastrin in the study group were higher than those in the healthy control group(P<0.05).The serum levels of Hcy,HSP60 and gastrin showed a gradual increase in the non-infected,type ll and the type group(P<0.05).The serum levels of Hcy,HSP60 and gastrin in the severe infection group were higher than those in the mild infection group(P<0.05).CONCLUSION The occurrence of Hp infection in patients with coronary heart disease could cause changes in levels of serum Hcy,HSP60 and gastrin,and at the same time levels of serum Hcy,HSP60 and gastrin were related to the serotype and infection degree of patients with coronary heart disease with Hp infection,which was expected to be a marker for predicting the Hp infection in patients with coronary heart disease.

关 键 词：冠心病 幽门螺杆菌 血清型 感染程度 同型半胱氨酸 热休克蛋白60 胃泌素 

分 类 号：R541.4[医药卫生—心血管疾病]