新冠疫情流行期间COVID-19感染与诱发皮肤病的关联  

Association of COVID-19 infection with induced dermatoses during the epidemic

作　　者：陈思珏 曹炜 肖显俊 石云舟 邹子豪 杨茜 陈明岭[2] 李瑛[1] CHEN Si-jue;CAO Wei;XIAO Xian-jun;SHI Yun-zhou;ZOU Zi-hao;YANG Qian;CHEN Ming-ling;LI Ying(Chengdu University of Traditional Chinese Medicine,Chengdu,Sichuan 610075,China;不详)

机构地区：[1]成都中医药大学针灸推拿学院,四川成都610075 [2]四川省中医院皮肤科,四川成都610075 [3]成都中医药大学养生康复学院,四川成都610075

出　　处：《中华医院感染学杂志》2024年第11期1720-1724,共5页Chinese Journal of Nosocomiology

基　　金：“十三五”国家重点研发计划基金资助项目(SQ2017YFC170007);国家自然科学基金资助项目(82205283);“针灸优势病种疗效评价国际合作研究”(2017YFC1703605);四川省中医药管理局科学技术研究专项基金资助项目(2021MS320)。

摘　　要：目的评估新冠病毒感染期间出现的皮肤病,确定与之相关的风险因素.方法通过"易表达"网页发放、回收问卷,收集人口统计学、基础病史和新冠病毒病史等信息.结果在1047份问卷中,有827份纳入分析,性别、慢性病史和年龄与新冠病毒期间的皮肤病无关;在多元逻辑分析中,有皮肤病史的受试者在感染新冠病毒期间出现皮肤病的概率是无皮肤病史的3.998倍(OR=3.998,95%CI:2.234~7.157),其中有疱疹病史的受试者出现皮肤病的概率是4.434倍(OR=4.434,95%CI:1.277~15.403),而荨麻疹史的受试者出现皮肤病的概率高达4.907倍(OR=4.907,95%CI:2.755~8.740);过敏史也是感染新冠病毒期间出现皮肤病的危险因素,有过敏史的患者出现皮肤病的概率是无过敏史的1.807倍(CR=1.807,95%CI:1.049~3.113).结论过敏史和皮肤病史是感染新冠病毒期间出现皮肤病的危险因素,尤其是荨麻疹和疱疹史,在感染SARS-CoV-2期间应注意可能出现皮肤病.OBJECTIVE To assess skin disorders presenting during COVID-19 infection and to identify possible risk factors associated with them.METHODS Questionnaires were distributed and returned through the Easy-Expression Webpage to collect information on demographics,basic medical history,and history of COVID-19.RESULTS Of 1047 questionnaires,827 were included in the analysis.Sex,history of chronic diseases,and age were not associated with skin disease during COVID-19.In multivariable analysis,patients with a history of dermatologic disease were 3.998-times more likely to develop skin disease during COVID-19 infection than those without a history of dermatologic disease(OR=3.998,95%CI:2.234-7.157),those with a history of herpes were 4.434 times more likely to develop skin diseases(OR=4.434,95%CI 1.277-15.403),while subjects with a history of urticaria were 4.907 times more likely to develop skin diseases(OR=4.907,95%CI 2.755-8.740).A history of allergy was also a risk factor for skin disease during COVID-19 infection,with patients with allergic being 1.807 times more likely than those without a history of allergy to develop skin disease during infection(OR=1.807,95%CI:1.049~3.113).CONCLUSION A history of allergic and dermatologic disease were risk factors for the development of skin disease during infection with COVID-19,especially a history of urticaria and herpes,and attention should be paid to the possibility of skin disease during infection with SARS-CoV-2.

关 键 词：新冠病毒感染 慢性疾病 过敏史 皮肤病史 皮肤病 

分 类 号：R246.7[医药卫生—针灸推拿学]