孕晚期阴道B族链球菌定植患者血清型和ASO、CL-1、miR-125及其对妊娠结局的预测价值  

Serotype and ASO,CCL-1,miR-125 in patients with vaginal group B streptococcus colonization in late pregnancy and their predictive value for pregnancy outcomes

作　　者：司秀云 司亚楠 鞠文艳 王德彦 SI Xiu-yun;SI Ya-nan;JU Wen-yan;WANG De-yan(Qingdao Hiser Hospital Affiliated of Qingdao University(Qingdao Traditional Chinese Medicine Hospital),Qingdao,Shandong 266033,China)

机构地区：[1]青岛大学附属青岛市海慈医院(青岛市中医医院)妇产科,山东青岛266033

出　　处：《中华医院感染学杂志》2024年第11期1730-1734,共5页Chinese Journal of Nosocomiology

基　　金：山东省医药卫生科技发展计划基金资助项目(2016WS0303)。

摘　　要：目的 探究孕晚期阴道B族链球菌定植患者血清型和抗链球菌溶血素O(ASO)、趋化细胞因子配体1(CCL-1)、微小核糖核酸(miR)-125及其对妊娠结局的预测价值.方法 选取2019年3月-2023年3月53例青岛大学附属青岛市海慈医院(青岛市中医医院)孕晚期阴道B族链球菌定植患者(研究组)和55名正常孕检女性(对照组),研究组根据妊娠结局分为正常组(27例)和不良组(26例);分析孕晚期阴道B族链球菌定植患者的血清型,比较两组血清ASO、CCL-1、miR-125水平及其对孕晚期阴道B族链球菌定植患者不良妊娠结局的预测价值.结果 53例孕晚期阴道B族链球菌定植患者血清型Ⅲ型为最常见,其余分别依次为Ⅰb型、Ⅴ型、Ⅰa型、Ⅱ型,Ⅳ型和NT型最少;与对照组相比,研究组血清ASO、CCL-1、miR-125水平升高(P<0.05);不良组血清ASO、CCL-1、miR-125水平高于正常组(P<0.05);血清ASO、CCL-1、miR-125联合检测对孕晚期阴道B族链球菌定植患者不良妊娠结局的诊断曲线下面积(AUC)值高于单独检测(P<0.05),且联合检测的敏感度为96.15%,特异度为88.89%.结论 孕晚期阴道B族链球菌定植患者常见血清型为Ⅲ型,此类患者血清ASO、CCL-1、miR-125水平高表达,且在妊娠结局不良患者中升高,三者联合检测对孕晚期阴道B族链球菌定植患者不良妊娠结局具有较高的诊断价值.OBJECTIVE To investigate serotype,anti-streptococcal hemolysin O(ASO),chemokine ligand 1(CCL-1),micrornas(miR-125)in patients with vaginal group B streptococcus colonization in late pregnancy and their predictive value for pregnancy outcome.METHODS Fifty-three patients with vaginal group B streptococcus colonization in Qingdao Haici Hospital affiliated to Qingdao University(Qingdao Hospital of Traditional Chinese Medicine)in late pregnancy(the study group)and 55 normal women(the control group)were selected from Mar.2019 to Mar.2023,and the patients of the study group were divided into the normal group(27 cases)and the adverse group(26 cases)according to pregnancy outcomes.The serotypes of patients with vaginal group B streptococcus colonization in late pregnancy were analyzed,and the serum levels of ASO,CCL-1 and miR-125 of the two groups were compared and their predictive value for adverse pregnancy outcomes in patients with vaginal group B streptococcus colonization in late pregnancy was compared.RESULTS Serotype II was the most common among 53 patients with vaginal group B streptococcus colonization in late pregnancy,and the rest were Ib,V,Ia,II,IV and NT,respectively.The levels of serum ASO,CCL-1 and miR-125 of the study group were higher than those of the control group(P<0.05).The serum levels of ASO,CCL-1 and miR-125 in the adverse group were higher than those in the normal group(P<0.05).The area under the curve(AUC)value of serum ASO,CCL-1 and miR-125 combined detection was higher than that of single detection for adverse pregnancy outcomes in patients with vaginal group B streptococcus colonization in late pregnancy(P<0.05),and the sensitivity and specificity of combined detection were 96.15%and 88.89%,respectively.CONCLUSION The common serotype of patients with vaginal group B streptococcus colonization in late pregnancy is type II,and the serum levels of ASO,CCL-1 and miR-125 in these patients are highly expressed,and elevated in patients with adverse pregnancy outcomes.The combined detection of the thr

关 键 词：孕晚期 B族链球菌 血清型 抗链球菌溶血素O 趋化细胞因子配体1 微小核糖核酸-125 不良妊娠结局 预测价值 

分 类 号：R378[医药卫生—病原生物学]