25羟基维生素D_(3)水平HCV-RNA载量及MPR对HCV感染患者抗病毒治疗效果的影响  

Influence of 25 hydroxy vitamin D_(3),HCV-RNA load and mean platelet volumes to platelet count ratio on the effect of antiviral therapy for patients with hepatitis C virus infection

作　　者：郭锐 李文娟 王亚娟 Guo Rui;Li Wenjuan;Wang Yajuan(Henan Provincial People's Hospital,Zhengzhou 450000,Henan,China)

机构地区：[1]河南省人民医院(郑州大学人民医院),河南郑州450000

出　　处：《临床心身疾病杂志》2024年第4期42-46,共5页Journal of Clinical Psychosomatic Diseases

基　　金：河南省医学科技攻关计划联合共建项目(编号LHGJ20200038)。

摘　　要：目的探讨25羟基维生素D_(3)[25-(OH)D_(3)]水平、HCV-RNA载量、平均血小板体积和血小板计数比率(MPR)对丙型肝炎病毒(HCV)感染患者抗病毒治疗效果的影响。方法回顾性分析104例HCV感染患者的病例资料,根据抗病毒治疗效果分为持续应答组47例和非持续应答组57例。比较持续应答组和非持续应答组患者的临床资料,以及治疗前血清25-(OH)D_(3)水平、HCV-RNA载量、MPR的差异。采用多因素Logistic回归分析探讨抗病毒治疗效果的影响因素,并采用受试者工作特征(ROC)曲线分析影响因素对治疗效果的联合预测价值。结果持续应答组患者年龄、体质量指数、HCV-RNA载量和MPR低于非持续应答组,血清25-(OH)D_(3)水平高于非持续应答患者(P<0.01)。Logistic回归分析结果显示,年龄、HCV-RNA载量和MPR是HCV感染患者抗病毒治疗效果的危险因素(P<0.01),血清25-(OH)D_(3)水平是保护因素(P<0.01)。ROC曲线分析结果显示,年龄、血清25-(OH)D_(3)水平、HCV-RNA载量、MPR联合预测HCV感染患者抗病毒治疗效果的曲线下面积为0.850(P<0.05),灵敏度和特异度分别为77.00%和86.00%。结论血清25-(OH)D_(3)水平、HCV-RNA载量、MPR在预测HCV感染患者抗病毒治疗效果方面有一定的价值,值得临床进一步研究。Objective To explore the influence of 25 hydroxy vitamin D_(3)(25-(OH)D_(3)),HCV-RNA load and mean platelet volumes to platelet count ratio(MPR)on the effect of antiviral therapy for patients with hepatitis C virus(HCV)infection.Methods Case data of 104 patients with HCV infection were retrospectively analyzed,according to the effects of antiviral treatment 47 ones set as sustained response(SR),and 57 patients set as non-SR group.The clinical data as well as pre-treatment differences in 25-(OH)D_(3)levels,HCV-RNA load,and MPR were compared between two groups.Pearson correlation analysis was used to explore the factors influencing the effect of antiviral treatment and receiver operating characteristic(ROC)curves were used to analyze combined predictive value of influencing factors for therapeutic effect.Results Age,body mass index,HCV-RNA load,and MPR were lower and serum 25-(OH)D_(3)level was higher in SR than non-SR group(P<0.01).Logistic regression analysis showed that age,HCV-RNA load,and MPR were risk factors for sustained response to antiviralt herapyin patients with HCV infection(P<0.01),while 25-(OH)D_(3)level was a protective factor(P<0.01).ROC curve analysis results showed that the area under the curve of age,25-(OH)D_(3)level,HCV-RNA load,and MPR combination predicting sustained response to antiviral therapy in patients with HCV infection was 0.850(P<0.05),sensitivity and specificity respectively 77.00%and 86.00%.Conclusion Serum 25-(OH)D_(3)level,HCV-RNA load,and MPR have certain value in predicting the sustained response of antiviral therapy in patients with HCV infection,as deserves further clinical research.

关 键 词：丙型肝炎病毒 25羟基维生素D_(3) HCV-RNA载量 平均血小板体积和血小板计数比率 持续应答 

分 类 号：R512.6[医药卫生—内科学]