干扰素诱导跨膜蛋白基因多态性与HBV感染程度的关联  

Association of gene polymorphism of interferon-induced transmembrane protein with the extent of HBV infection

作　　者：王博文 王强 黄严春 章革民 陈华 朱雄林 WANG Bo-wen;WANG Qiang;HUANG Yan-chun;ZHANG Ge-min;CHEN Hua;ZHU Xiong-lin(Wuhan Xinzhou District People's Hospital,Wuhan,Hubei 430400,China;不详)

机构地区：[1]武汉市新洲区人民医院感染内科,湖北武汉430400 [2]武汉市金银潭医院感染内科,湖北武汉430048

出　　处：《中华医院感染学杂志》2024年第12期1784-1788,共5页Chinese Journal of Nosocomiology

基　　金：湖北省卫生健康委员会联合基金资助项目(WJ2020H19)。

摘　　要：目的探究干扰素诱导跨膜蛋白(IFITM)基因多态性与乙型肝炎病毒(HBV)感染程度的关系.方法选择2017年1月-2021年1月武汉市新洲区人民医院收治的104例HBV感染患者为研究组,按照HBV感染损伤肝功能的程度将患者分为A组(Child-Pugh A级,n=31)、B组(Child-Pugh B级,n=30)和C组(Child-Pugh C级,n=43),选择同一时间段内于医院进行体检的90名健康体检者为对照组;采用直接测序法检测IFITM基因多态性,并采用Logistic回归分析IFITM3基因多态性与HBV感染程度的关联.结果研究组IFITM3基因rs12252位点CC基因型、C等位基因频率高于对照组(P<0.05);不同HBV感染程度患者IFITM3基因rs12252位点CC基因型、C等位基因频率比较,差异有统计学意义(P<0.05);Logistic回归分析结果显示,IF-ITM3基因rs12252位点加性模式中携带CC基因型者HBV重度感染风险是携带TT基因型者的3.600倍(P<0.05),rs12252位点隐性模式中携带CC基因型者HBV重度感染风险是携带TT+TC基因型者的3.527倍(P<0.05);IFITM3基因rs12252位点CC基因型是HBV感染程度的危险因素(P<0.05).结论IFITM3基因rs12252位点多态性与HBV感染程度相关,CC基因型可能增加重度HBV感染风险.OBJECTIVE To investigate the relationship between interferon-induced transmembrane protein(IFITM)gene polymorphism and the extent of hepatitis B virus(HBV)infection.METHODS 104 patients with HBV infection admitted to Wuhan Xinzhou District People's Hospital between Jan.2017 and Jan.2021 were selected as the study group and were divided into group A(Child-Pugh grade A,n=31),group B(Child-Pugh grade B,n=30)and group C(Child-Pugh grade C,n=43)according to the severity of liver function injury caused by HBV infection.9o healthy people who underwent physical examination in the hospital during the same period were enrolled as the control group.Direct sequencing was used to detect IFITM gene polymorphism,and Logistic regression analysis was used to analyze the association between IFITM3 gene polymorphism and degree of HBV infection.RESULTS The frequencies of CC genotype and C allele at the rs12252 locus of IFITM3 gene in the study group were higher than those in the control group(P<0.05).There were statistically significant differences in the frequencies of CC genotype and C allele at the rs12252 locus of IFITM3 gene among patients with different degrees of HBV infection(P<0.05).Logistic regression analysis showed that the risk of severe HBV infection in patients carrying CC genotype under additive mode of rs12252 locus of IFITM3 gene was 3.600 times that of patients carrying the TT genotype(P<0.05).In the recessive mode of rs12252 locus,the risk of severe HBV infection in patients with CC genotype was 3.527 times that of patients with TT+TC genotype(P<0.05).CC genotype at the rs12252 locus of IFITM3 gene was a risk factor for the extent of HBV infection(P<0.05).CONCLUSION Polymorphisms at the rs12252 locus of the IFITM3 gene were associated with the degree of HBV infection,and the CC genotype might increase the risk of severe HBV infection.

关 键 词：干扰素诱导跨膜蛋白 基因多态性 乙型肝炎病毒 感染程度 关联性 

分 类 号：R512.62[医药卫生—内科学]