化疗对子宫内膜癌患者术后阴道残端感染和阴道微生态平衡的影响  

Effect of chemotherapy on postoperative vaginal stump infection and vaginal microecological balance in patients with endometrial cancer

作　　者：王雪娟 卢玲 刘芳 WANG Xue-juan;LU Ling;LIU Fang(People's Hospital of Shijiazhuang City,Shijiazhuang,Hebei 05003l,China;不详)

机构地区：[1]石家庄市人民医院妇三科,河北石家庄050031 [2]故城县医院妇产科,河北衡水253809

出　　处：《中华医院感染学杂志》2024年第12期1845-1848,共4页Chinese Journal of Nosocomiology

基　　金：河北省医学科学研究基金资助项目(20220010);石家庄市科学技术研究与发展计划基金资助项目(201460613)。

摘　　要：目的分析子宫内膜癌术后化疗对患者阴道残端感染和阴道微生态平衡的影响.方法选择2019年9月-2021年9月石家庄市人民医院行根治手术的82例子宫内膜癌患者为研究对象,随机分为研究组与对照组,各41例;研究组41例术后予以化疗,对照组41例术后未进行化疗;比较两组术后6个月内阴道残端感染情况及阴道微生态平衡状况,评估两组手术前后的肿瘤标记物水平,评价两组两年内的复发、转移率及总体生存率.结果研究组阴道残端感染率、阴道清洁度异常率及病原体感染率高于对照组(P<0.05);术后6个月,两组糖类抗原125(CA125)、糖类抗原199(CA199)、糖类抗原153(CA153)水平均降低,且研究组低于对照组(P<0.05);研究组2年内复发率及转移率均低于对照组(P<0.05);研究组2年内总体生存率高于对照组(P<0.05).结论子宫内膜癌根治术后化疗可破坏阴道微生态平衡,增加阴道残端感染的风险,但能有效降低患者的肿瘤标记物水平,改善患者的短期预后,提高患者的短期生存率.OBJECTIVE To analyze the effect of postoperative chemotherapy on vaginal stump infection and vaginal microecological balance in patients with endometrial carcinoma.METHODS Totally 82 patients with endometrial cancer who underwent radical surgery in Shijiazhuang People'shospital from Sep.2019 to Sep.2021 were selected as the research subjects and randomly divided into the study and the control groups,with 4l cases in each group.The patients in the study group were treated with chemotherapy after operation,while patients in the control group were not treated with chemotherapy after operation.The vaginal stump infection and vaginal microecological balance were compared between the two groups within 6 months after operation,the levels of tumor marker before and after operation were evaluated,and the recurrence,metastasis rate and overall survival rate within 2 years were evaluated.RESULTS The infection rate of vaginal stump,abnormality rate of vaginal cleanliness and pathogen infection rate in the study group were higher than those in the control group(P<o.05).At 6 months after surgery,the levels of glycoantigen125(CA125),glycoantigen 199(CA199)and glycoantigen 153(CA153)were reduced in both groups,and were lower in the study group than in the control group(P<o.05).Relapse rate and metastasis rates within 2 years rate in the study group were lower than those in the control group(P<0.05).The overall survival rate within 2 years in the study group was higher than that in the control group(P<o.05).CONCLUSION Chemotherapy after radical hysterectomy of endometrial carcinoma can disrupt the vaginal microecological balance and increase the risk of vaginal stump infection,but it can effectively reduce the levels of tumor marker,improve their short-term prognosis and increase the short-term survival rate of patients.

关 键 词：子宫内膜癌 术后化疗 阴道残端感染 阴道微生态平衡 血清肿瘤标记物 预后 

分 类 号：R711.74[医药卫生—妇产科学]