侵袭性念珠菌病研究进展  

Advances in research on invasive candidiasis

作　　者：康慧 赵静雅 李定辰 陈芳艳 林杨轩 韩黎 KANG Hui;ZHAO Jing-ya;LI Ding-chen;CHEN Fang-yan;LIN Yang-xuan;HAN Li(Zhengzhou University,Zhengzhou,Henan 45000l,China;不详)

机构地区：[1]郑州大学公共卫生学院,河南郑州450001 [2]中国人民解放军疾病预防控制中心消毒与感染控制科,北京100071 [3]安徽医科大学公共卫生学院,安徽合肥230032

出　　处：《中华医院感染学杂志》2024年第12期1908-1913,共6页Chinese Journal of Nosocomiology

基　　金：国家自然科学基金资助项目(82172293,81971914)。

摘　　要：侵袭性念珠菌病(IC)是最常见的真菌感染性疾病,临床诊断困难,伴有极高的发病率和病死率,给危重症患者和免疫力低下的人群带来严重的负担.白假丝酵母是世界上大多数地区IC重点致病菌,但近年来,非白假丝酵母在一些国家和地区逐渐成为优势菌种,给临床治疗带来了极大的困难,本文综述了目前IC最新的流行病学研究进展,深入探讨IC在高危人群中的流行现状以及致病菌种的变化趋势,以期为IC的诊疗防治提供参考.Invasive candidiasis(IC)is the most common fungal infectious disease,which is difficult to diagnose clinically,accompanied by very high morbidity and mortality,and poses a serious disease burden to critically ill patients and immunocompromised individuals.Candida albicans has been the major causative agent of IC in most parts of the world,but in recent years,non-Candida albicans has gradually become the dominant species in some countries and regions,which has brought great difficulties in clinical management.This article reviews the latest epidemiologic progress of IC,and discusses in depth the current epidemiologic status of IC in high-risk populations as well as the trend of causative species,with the aim of providing new theoretical basis for the diagnosis and prevention of IC.

关 键 词：假丝酵母 侵袭性念珠菌病 高危人群 致病菌 临床表现 流行病学 预防控制 

分 类 号：R378[医药卫生—病原生物学]