健脾涤痰汤联合常规西药治疗急性加重期慢性阻塞性肺疾病痰浊阻肺证临床研究  

Clinical Study on Jianpi Ditan Decoction Combined with Western Medicine for Acute Exacerbation of Chronic Obstructive Pulmonary Disease with Syndrome of Turbid Phlegm Obstructing the Lung

作　　者：许洁 孟丽丽 朱晓鹏 XU Jie;MENG Lili;ZHU Xiaopeng(Tianshui Wulin Community Health Service Center of Gongshu District,Hangzhou Zhejiang 310005,China;Pharmacy of Chinese Medicine,Hangzhou Women's Hospital,Hangzhou Zhejiang 310008,China)

机构地区：[1]杭州市拱墅区天水武林街道社区卫生服务中心,浙江杭州310005 [2]杭州市妇产科医院中药房,浙江杭州310008

出　　处：《新中医》2024年第11期44-48,共5页New Chinese Medicine

摘　　要：目的:观察健脾涤痰汤联合常规西药治疗急性加重期慢性阻塞性肺疾病(AECOPD)痰浊阻肺证的临床效果。方法:回顾性选取78例AECOPD痰浊阻肺证患者,按治疗方法不同分为对照组和观察组各39例。对照组给予常规西药治疗,观察组在对照组基础上给予健脾涤痰汤治疗,2组连续治疗10 d。评价2组临床疗效,比较2组肺功能、中医证候评分、慢性阻塞性肺疾病患者自我评估测试问卷(CAT)评分及血清S100钙结合蛋白A8/A9复合物(S100A8/A9)和核因子(NF)-κB水平。结果:观察组总有效率为94.87%,高于对照组74.36%(P<0.05)。治疗后,2组CAT评分较治疗前降低(P<0.05),且观察组CAT评分低于对照组(P<0.05)。治疗后,2组第1秒用力呼气容积(FEV1)、FEV1占用力肺活量(FVC)百分比(FEV1/FVC)较治疗前升高(P<0.05),且观察组FEV1、FEV1/FVC高于对照组(P<0.05)。治疗后,2组各项中医证候评分较治疗前降低(P<0.05),且观察组各项中医证候评分低于对照组(P<0.05)。治疗后,2组血清S100A8/A9、NF-κB水平较治疗前降低(P<0.05),且观察组血清S100A8/A9、NF-κB水平低于对照组(P<0.05)。结论:健脾涤痰汤联合西医常规疗法治疗AECOPD痰浊阻肺证的临床效果明显,有利于病情的控制,促进肺功能、中医证候的好转,以及抑制炎症反应。Objective:To observe the clinical effect of the therapy of Jianpi Ditan Decoction combined with western medicine on acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with syndrome of turbid phlegm obstructing the lung.Methods:A total of 78 AECOPD patients with syndrome of turbid phlegm obstructing the lung were retrospectively selected and divided into the control group and the observation group,with 39 cases in each group.The control group was treated with conventional western medicine,and the observation group was treated with Jianpi Ditan Decoction combined with western medicine based on the treatment of the control group.The two groups were treated for 10 days.The clinical effects in the two groups were evaluated,and the lung function,traditional Chinese medicine(TCM)syndrome scores,COPD Assessment Test(CAT),and levels of serum S100 calcium binding protein A8/A9 complex(S100A8/A9)and nuclear factor-κB(NF-κB)were compared in the two groups.Results:The total effective rate was 94.87%in the observation group,higher than that of 74.36%in the control group(P<0.05).After treatment,the CAT scores in the two groups were decreased when compared with those before treatment(P<0.05),and the CAT score in the observation group was lower than that in the control group(P<0.05).After treatment,the forced expiratory volume in the first second(FEV1)and the percentage of FEV1 to forced vital capacity(FVC)(FEV1/FVC)in the two groups were increased when compared with those before treatment(P<0.05),and the FEV1 and FEV1/FVC in the observation group were higher than those in the control group(P<0.05).After treatment,the TCM syndrome scores in the two groups were decreased when compared with those before treatment(P<0.05),and the TCM syndrome scores in the observation group were lower than those in the control group(P<0.05).After treatment,the serum levels of S100A8/A9 and NF-κB in the two groups were decreased when compared with those before treatment(P<0.05),and the serum levels of S100A8/A9 and NF-κB in the ob

关 键 词：急性加重期慢性阻塞性肺疾病 健脾涤痰汤 S100钙结合蛋白A8/A9复合物 核因子-κB 肺功能 炎症反应 

分 类 号：R563[医药卫生—呼吸系统]