疏肝润肠方治疗肝郁气滞型便秘临床研究  

Clinical Study on Shugan Runchang Prescription for Constipation of Liver Constraint and Qi Stagnation Type

作　　者：李晓洁[1] 张胜威[1] 王华胜[1] 王东[1] LI Xiaojie;ZHANG Shengwei;WANG Huasheng;WANG Dong(The Fifth Clinical Medical School of Henan University of Chinese Medicine,People's Hospital of Zhengzhou,Zhengzhou Henan 450000,China)

机构地区：[1]河南中医药大学第五临床医学院/郑州人民医院,河南郑州450000

出　　处：《新中医》2024年第11期49-53,共5页New Chinese Medicine

基　　金：河南省卫生健康委员会国家中医临床研究基地科研专项(2022JDZX149)。

摘　　要：目的:观察疏肝润肠方治疗肝郁气滞型便秘的临床疗效。方法:采用随机数字表法将64例肝郁气滞型便秘患者分为对照组和观察组各32例。对照组给予比沙可啶肠溶片口服治疗,观察组给予疏肝润肠方口服治疗。治疗4周后,比较2组完全自主排便次数(CSBM)、便秘症状积分、中医证候积分、便秘患者生活质量量表(PAC-QOL)评分及血清P物质(SP)、血管活性肠肽(VIP)、胃动素(MTL)、胃泌素(GAS)、5-羟色胺(5-HT)水平,并评估2组临床疗效和不良反应发生率。结果:观察组总有效率为93.75%,高于对照组75.00%(P<0.05)。治疗后,2组便秘症状评分、中医证候积分、PAC-QOL评分均较治疗前降低,且观察组低于对照组(P<0.05);2组CSBM较治疗前升高,且观察组CSBM高于对照组(P<0.05)。治疗后,2组5-HT、SP、MTL、GAS水平较较治疗前升高,VIP水平较治疗前降低(P<0.05);且观察组5-HT、SP、MTL、GAS水平高于对照组,VIP水平低于对照组(P<0.05)。结论:疏肝润肠方可有效改善肝郁气滞证便秘患者的便秘症状和中医证候,提高患者生活质量,调节机体胃肠激素水平。Objective:To observe the clinical effect of Shugan Runchang Prescription on constipation of liver constraint and qi stagnation type.Methods:A total of 64 patients with constipation of liver constraint and qi stagnation type were divided into the control group and the observation group according to the random number table method,with 32 cases in each group.The control group was given oral administration of Bisacodyl Enteric-Coated Tablets for treatment,and the observation group was treated with oral administration of Shugan Runchang Prescription.After four weeks of treatment,the complete spontaneous bowel movement(CSBM)frequency,scores of constipation symptoms,traditional Chinese medicine(TCM)syndrome scores,scores of Patient Assessment of Constipation-Quality of Life(PAC-QOL)and the levels of serum substance P(SP),vasoactive intestinal peptide(VIP),motilin(MTL),gastrin(GAS)and 5-hydroxytryptamine(5-HT)were compared between the two groups.The clinical effects and incidence of adverse reactions in the two groups were evaluated.Results:The total effective rate was 93.75%in the observation group,higher than that of 75.00%in the control group(P<0.05).After treatment,the scores of constipation symptoms,TCM syndrome scores,PAC-QOL scores in the two groups were decreased when compared with those before treatment(P<0.05),and the above three scores in the observation group were lower than those in the control group(P<0.05);the CSBM frequency in the two groups was increased when compared with that before treatment,and the CSBM frequency in the observation group was higher than that in the control group(P<0.05).After treatment,the levels of 5-HT,SP,MTL and GAS in the two groups were increased when compared with those before treatment(P<0.05),and the VIP levels were decreased when compared with those before treatment(P<0.05);the levels of 5-HT,SP,MTL and GAS in the observation group were higher than those in the control group(P<0.05),and the VIP level was lower than that in the control group(P<0.05).Conclusion:Shugan Runchang

关 键 词：便秘 肝郁气滞型 疏肝润肠方 神经递质 生活质量 中医证候积分 

分 类 号：R442.2[医药卫生—诊断学]