抗血管内皮生长因子药物玻璃体腔注射联合激光光凝治疗重度非增殖性糖尿病视网膜病变伴黄斑水肿的临床研究  

Clinical Study of Intravitreal Injection of Anti-vascular Endothelial Growth Factor Drugs Combined with Laser Photocoagulation in the Treat⁃ment of Severe Non-proliferative Diabetic Retinopathy with Macular Edema

作　　者：秦剑莺 顾育红 王在方 QIN Jianying;GU Yuhong;WANG Zaifang(Department of Ophthalmology,Changshu Hospital Affiliated to Soochow University(Changshu First People's Hospital),Changshu,Jiangsu Province,215500 China)

机构地区：[1]苏州大学附属常熟医院(常熟市第一人民医院)眼科,江苏常熟215500

出　　处：《中外医疗》2024年第14期9-12,共4页China & Foreign Medical Treatment

摘　　要：目的探究抗血管内皮生长因子药物玻璃体腔注射联合激光光凝治疗重度非增殖性糖尿病视网膜病变伴黄斑水肿的临床效果。方法前瞻性随机选取2020年3月—2023年3月因重度非增殖性糖尿病视网膜病变伴黄斑水肿在常熟市第一人民医院眼科门诊诊疗的80例患者进行研究,根据抛硬币法随机分为两组,各组40例,对照组予以全视网膜激光光凝治疗,观察组予以抗血管内皮生长因子药物玻璃体腔注射+全视网膜激光光凝治疗。比较整体临床疗效。结果观察组治疗总有效率高达95.00%,比对照组80.00%显著更高,差异有统计学意义(χ^(2)=4.114,P<0.05);观察组术后1、3、6个月的视力水平和黄斑中心视网膜厚度优于对照组,差异有统计学意义(P均<0.05);观察组术后并发症发生率12.50%和对照组20.00%比较,差异无统计学意义(P>0.05)。结论重度非增殖性糖尿病视网膜病变合并黄斑水肿患者采用玻璃体腔注射抗血管内皮生长因子+激光光凝治疗法,可发挥安全有效的治疗作用。Objective To explore the clinical effect of intravitreal injection of anti-vascular endothelial growth factor drugs combined with laser photocoagulation in the treatment of severe non-proliferative diabetic retinopathy with macular edema.Methods 80 patients with severe non-proliferative diabetic retinopathy accompanied by macular edema in the ophthalmic outpatient department of Changshu First People's Hospital from March 2020 to March 2023 were prospective randomly selected for study.They were randomly divided into two groups with forty each according to the coin toss method.The control group was treated with full retinal laser photocoagulation,and the observation group was treated with intravitreal injection of anti-vascular endothelial growth factor and full retinal laser photocoagulation.The overall clinical effect was compared.Results The total effective rate of observation group was 95.00%,which was significantly higher than that of control group 80.00%,and the difference was statistically significant(χ^(2)=4.114,P<0.05).The visual acuity level and macular central retinal thickness of the observation group were better than those of the control group one month,three months and six months after operation,and the differences were statistically significant(all P<0.05).There was no statistically significant difference in the incidence of postoperative complications be-tween the observation group and the control group(12.50%and 20.00%)(P>0.05).Conclusion It is a safe and effective treatment for patients with severe non-proliferative diabetic retinopathy complicated with macular edema by intra-vitreal injection of anti-vascular endothelial growth factor and laser photocoagulation.

关 键 词：抗血管内皮生长因子 玻璃体腔注射 激光光凝 重度非增殖性糖尿病视网膜病变 黄斑水肿 

分 类 号：R4[医药卫生—临床医学]