^(131)I治疗GD甲亢的效果分析  

Analysis of the Effect of ^(131)I in the Treatment of GD Hyperthyroidism

作　　者：张兵 尤嘉熙[1] 苏桂林 ZHANG Bing;YOU Jiaxi;SU Guilin(Department of Nuclear Medicine,the Second Affiliated Hospital of Soochow University,Suzhou,Jiangsu Province,215101 China)

机构地区：[1]苏州大学附属第二医院核医学科,江苏苏州215101

出　　处：《中外医疗》2024年第15期79-81,90,共4页China & Foreign Medical Treatment

摘　　要：目的探讨毒性弥漫性甲状腺肿(Graves Disease,GD)甲亢采用^(131)I治疗的效果。方法前瞻性随机选取苏州大学附属第二医院于2021年9月—2023年9月接诊的100例GD甲亢患者为研究对象,根据治疗方式的不同进行分组,每组50例。观察组实施^(131)I治疗,对照组采用甲巯咪唑治疗,比较两组临床治疗效果。结果观察组治疗总有效率为98.00%,高于对照组,差异有统计学意义(χ^(2)=4.396,P<0.05)。治疗后,观察组两组促甲状腺激素、游离三碘甲状腺原氨酸、游离四碘甲状腺原氨酸水平均优于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组I型原胶原N端前肽、骨钙素、碱性磷酸酶水平更优于对照组,差异有统计学意义(P均<0.05)。结论GD甲亢实施^(131)I治疗的临床效果较为明显,可以改善患者的甲状腺功能指标以及骨代谢指标,不良反应较少。Objective To investigate the effect of ^(131)I treatment for hyperthyroidism in Graves disease(GD).Methods 100 cases of GD hyperthyroidism patients who were diagnosed in the Second Affiliated Hospital of Soochow University from September 2021 to September 2023 were prospective randomly selected as the study subjects,and they were grouped according to the different treatment modes,with 50 cases in each group.The observation group implemented ^(131)I treatment,and the control group was treated with methimazole,comparing the clinical treatment effects of the two groups.Results The total effective rate of treatment in the observation group was 98.00%,which was higher than that in the control group,and the difference was statistically significant(χ^(2)=4.396,P<0.05).After treatment,the levels of thyroid-stimulating hormone,free triiodothyronine and free tetraiodothyronine in the observation groups were better than those in the control group,and the differences were statistically significant(all P<0.05).After treatment,the lev⁃els of type I procollagen N-terminal propeptide,osteocalcin and alkaline phosphatase in the observation group were more favorable than those in the control group,and the differences were statistically significant(all P<0.05).Conclu⁃sion The clinical effect of ^(131)I treatment in GD hyperthyroidism is more obvious,and it can improve patients'thyroid function indexes as well as bone metabolism indexes,with fewer adverse reactions.

关 键 词：毒性弥漫性甲状腺肿 甲亢 ^(131)I治疗 疗效评估 

分 类 号：R581[医药卫生—内分泌]