去白细胞悬浮红细胞输血技术在急救输血中的实践及进展研究  

Research on the Practice and Progress of Dewhite Blood Cell Suspension Red Blood Cell Transfusion Technology in Emergency Blood Transfusion

作　　者：金凡力 张晓然[2] JIN Fanli;ZHANG Xiaoran(Department of Blood Transfusion,Siping Central People's Hospital,Siping,Jilin Province,136000 China;Department of Blood Transfusion,Siping Maternal and Child Hospital,Siping,Jilin Province,136000 China)

机构地区：[1]四平市中心人民医院输血科,吉林四平136000 [2]四平市妇婴医院输血科,吉林四平136000

出　　处：《中外医疗》2024年第15期185-189,共5页China & Foreign Medical Treatment

摘　　要：去白细胞悬浮红细胞指分离白细胞后所剩的红细胞悬浮液,适用于大量失血患者的急救输血中。白细胞会引起相关病毒传播及介导输血反应,去白细胞可以确保患者输血安全。本文对悬浮红细胞输血中的去白细胞方法进行研究,不同方法的白细胞去除率与红细胞回收率有所不同,制备悬浮红细胞主要采用第三代去白细胞过滤器,白细胞去除率超过99%。第四代白细胞过滤器使用的材料更加丰富,相关研究正在逐步开展,有待获得更充足的临床证据。有效去白细胞对于悬浮红细胞输血具有重要实践意义,可以防止人类白细胞抗原同种异体免疫,减少发热非溶血性输血相关反应,降低白细胞相关传染病风险,同时预防输血后移植物抗宿主病。Red blood cell suspension refers to the remaining red blood cell suspension after separating white blood cells,which is suitable for emergency blood transfusion in large numbers of patients with blood loss.White blood cells can cause the spread of related viruses and mediate transfusion reactions.Removing white blood cells can ensure the safety of blood transfusions for patients.This article studies the methods of removing white blood cells in suspended red blood cell transfusion.The white blood cell removal rate and recovery rate of different methods vary.The prepara⁃tion of suspended red blood cells mainly uses third-generation white blood cell removal filters,with a white blood cell removal rate exceeding 99%.The materials used in the fourth generation white blood cell filters are more diverse,and related research is gradually being carried out,requiring more sufficient clinical evidence.Effective removal of white blood cells is of great practical significance for suspended red blood cell transfusion,as it can prevent allogeneic im⁃munity to human leukocyte antigen,reduce fever related non hemolytic transfusion related reactions,reduce the risk of white blood cell related infectious diseases,and prevent graft-versus-host disease after transfusion.

关 键 词：急救输血 输血技术 去白细胞 悬浮红细胞 综述 

分 类 号：R457[医药卫生—治疗学]