血清IL-6、PCT、SAA、CRP在老年细菌性肺炎患者中的表达及对病情评估的价值  

Expression of Serum IL-6,PCT,SAA and CRP in Elderly Patients with Bacterial Pneumonia and Their Value in Disease Assessment

作　　者：陈磊 郭锋 Chen Lei;Guo Feng(Medical Laboratory,Sanmenxia Central Hospital,Sanmenxia,Henan,472099,China)

机构地区：[1]三门峡市中心医院医学检验科,河南三门峡472099

出　　处：《黑龙江医学》2024年第13期1589-1591,共3页Heilongjiang Medical Journal

摘　　要：目的:探讨白介素-6 (IL-6)、降钙素原(PCT)、血清淀粉样蛋白(SAA)、C-反应蛋白(CRP)在细菌性肺炎中的表达差异,分析其对病情评估的价值。方法:回顾性分析2020年4月—2023年3月三门峡市中心医院治疗的300例老年肺炎患者作为研究组,按照不同类别分为细菌性肺炎组130例和非细菌性肺炎组170例。同期收集100例老年健康体检者作为对照组,比较血清IL-6、PCT、SAA、CRP在各组间的表达差异,利用受试者工作曲线(ROC)分析其对老年细菌性肺炎的诊断价值,采用Pearson线性分析社区获得性肺炎(CURB-65)评分与各指标的关系。结果:老年细菌性肺炎患者血清IL-6、PCT、SAA、CRP水平明显升高,差异有统计学意义(F=23.766、25.349、25.344、29.207,P<0.05)。IL-6、PCT、SAA、CRP诊断细菌性肺炎的曲线下面积分别为0.801、0.810、0.752、0.601,四项联合检测的曲线下面积为0.886,灵敏度和特异度分别为90.0%、82.2%,具有较高的诊断价值。血清IL-6、PCT、SAA、CRP水平随病情加重而逐渐升高,高危组明显高于中危组、低危组,差异有统计学意义(F=19.089、19.313、15.276、13.770,P<0.05)。根据Pearson线性相关性分析可知,CURB-65与RDW、NLR、CRP呈正相关(P<0.05)。结论:血清IL-6、PCT、SAA、CRP水平在老年细菌性肺炎患者中明显升高,且与患者病情严重程度相关,可用于疾病早期诊断及评估疾病进展。Objective:To investigate the differences in the expression of interleukin-6(IL-6),procalcitonin(PCT),serum amyloid protein(SAA)and C-reactive protein(CRP)in bacterial pneumonia,and to analyze their value in the evaluation of the disease.Methods:300 elderly patients with pneumonia treated in the hospital from April 2020 to March 2023 were retrospectively collected as research group,and they were divided into 130 cases in bacterial pneumonia group and 170 cases in non-bacterial pneumonia group according to different categories.During the same period,100 healthy elderly subjects were collected as the control group.The expression differences of IL-6,PCT,SAA and CRP among all groups were compared.The diagnostic value of IL-6,PCT,SAA and CRP was analyzed by receiver operating curve(ROC),and the relationship between CURB-65 score,and each index was analyzed by Pearson linear analysis.Results:Serum levels of IL-6,PCT,SAA and CRP were significantly increased in elderly patients with bacterial pneumonia,with statistically significant difference(F=23.766,25.349,25.344,29.207;P<0.05).The areas under the curve of IL-6,PCT,SAA and CRP in the diagnosis of bacterial pneumonia were 0.801,0.810,0.752 and 0.601,respectively.The area under the curve of the four combined tests was 0.886,and the sensitivity and specificity were 90.0%and 82.2%,respectively,which had high diagnostic value.The serum levels of IL-6,PCT,SAA and CRP increased gradually with the exacerbation of the disease.The levels of high-risk group were significantly higher than those in middle-risk group and low-risk group,with statistically significant difference(F=19.089,19.313,15.276,13.770;P<0.05).According to Spearman correlation analysis,CURB-65 score was positively correlated with RDW,NLR and CRP(P<0.05).Conclusion:Serum levels of IL-6,PCT,SAA and CRP are significantly increased in elderly patients with bacterial pneumonia,which is related to the severity of patients’disease,and can be used for early diagnosis and evaluation of disease progression.

关 键 词：老年 细菌性肺炎 白介素-6 降钙素原 血清淀粉样蛋白 C-反应蛋白 

分 类 号：R563.1[医药卫生—呼吸系统]