关于国际法医遗传学学会(ISFG)对STR序列命名建议的解读  

Interpretation of the international society of forensic genetics(ISFG)'s recommendations for STR sequence nomenclature

作　　者：刘志勇 赵凯[3] 孙宏钰[1,2] Liu Zhiyong;Zhao Kai;Sun Hongyu(Faculty of Forensic Medicine,Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou 510080,China;Guangdong Province Translational Forensic Medicine Engineering Technology Research Center,Guangzhou 510080,China;The Center of Criminal Technology of Guangdong Province,Guangzhou 510050,China)

机构地区：[1]中山大学中山医学院法医学系,广东广州510080 [2]广东省法医学转化医学工程技术研究中心,广东广州510080 [3]广东省公安厅刑事技术中心,广东广州510050

出　　处：《中国法医学杂志》2024年第3期361-367,共7页Chinese Journal of Forensic Medicine

基　　金：国家自然科学基金面上项目(81971798)。

摘　　要：基于大规模平行测序(MPS)技术的STR分型在法医DNA检验中的应用日益广泛,但是STR等位基因序列命名规则不统一及自动化程度低的问题阻碍了实验室之间的数据共享与比对,也不利于基于序列多态性的STR数据库构建。国际法医遗传学学会(ISFG)近期发布了对STR序列命名的建议,预期将对这个问题的解决有所改善。本文回顾了ISFG关于STR命名的历程,对该建议的主要内容进行解读,并与目前国内司法和公安行业现行的相关规范进行比较,以期帮助同行理解和使用。STR sequence typing based on massively parallel sequencing(MPS) technology is increasingly used in forensic DNA typing,but the problem of inconsistent rules for naming STR sequences and low automation hinder data sharing and comparison between laboratories,and is not conducive to build STR databases based on sequence polymorphisms.The International Society of Forensic Genetics(ISFG) has recently published recommendations for STR sequence nomenclature,which is expected to solve this problem.This paper reviews the ISFG's journey on STR naming,interprets the main content of the recommendations,and compares it with the current relevant standards existing in the domestic judice and public security industries,with the aim of helping peers to understand and use it.

关 键 词：STR命名 国际法医遗传学学会 毛细管电泳 大规模平行测序 

分 类 号：D919.2[医药卫生—法医学]