咬肌肉毒毒素注射后严重皮下血肿1例及文献回顾  

Severe subcutaneous hematoma after injection of botulinum toxin into the masseter muscle:a case report and literature review

作　　者：易珂敏 王先成[1] 孙杨[1] 熊祥[1] 孟宪熙 李文波 易忠杰 乔治华 李孝汀 熊乃辛 Yi Kemin;Wang Xiancheng;Sun Yang;Xiong Xiang;Meng Xianxi;Li Wenbo;Yi Zhongjie;Qiao Zhihua;Li Xiaoting;Xiong Naixin(Department of Plastic and Aesthetic(Burn)Surgery,the Second Xiangya Hospital,Central South University,Changsha 410011,China)

机构地区：[1]中南大学湘雅二医院整形美容(烧伤)外科,长沙410011

出　　处：《中华整形外科杂志》2024年第6期668-673,共6页Chinese Journal of Plastic Surgery

摘　　要：患者男,29岁,有血友病病史10余年,咬肌注射肉毒毒素6 h后出现右面部红肿逐渐加重伴青紫,伴局部疼痛、张口受限等症状,予输注凝血因子Ⅸ7 d后血肿较前吸收,肿胀明显消退。血友病患者注射肉毒毒素后产生大面积血肿的案例鲜见报道,该文总结了该病例的诊治过程并结合文献回顾,为诊治和预防类似并发症提供了临床经验。The patient was a 29-year-old male with a history of hemophilia for more than 10 years.After 6 hours of botulinum toxin injection into the masseter muscle,the redness and swelling of the right face gradually worsened,accompanied by local pain,and restricted mouth opening,etc.The hematoma was absorbed and the swelling subsided significantly after the infusion of coagulation factorⅨ.Such cases of large-scale hematomas after botulinum toxin injection in hemophiliacs is rarely reported.This article summarized the diagnosis and treatment process of this case and combines with literature review to provide clinical experience for diagnosis,treatment and prevention of similar complications.

关 键 词：肉毒毒素类 并发症 血肿 血友病 

分 类 号：R62[医药卫生—整形外科]