Interferon-induced MXB protein restricts vimentin-dependent viral infection  

作　　者：Dongrong Yi Ni An Quanjie Li Qian Liu Huihan Shao Rui Zhou Jing Wang Yongxin Zhang Ling Ma Fei Guo Xiaoyu Li Zhenlong Liu Shan Cen 

机构地区：[1]Institute of Medicinal Biotechnology,Chinese Academy of Medical Science,Beijing 100050,China [2]Institute of Pathogen Biology,Chinese Academy of Medical Science,Beijing 100730,China [3]Lady Davis Institute for Medical Research,Jewish General Hospital,Montreal,Quebec H3T 1E2,Canada

出　　处：《Acta Pharmaceutica Sinica B》2024年第6期2520-2536,共17页药学学报（英文版）

基　　金：appreciate the National Microbial Resource Center(No.NMRC-2020-3);the CAMS Collection Center of Pathogenic Microorganisms(CAMS-CCPM-A)for providing valuable reagents;supported by Beijing Natural Science Foundation 7242097(to Dongrong Yi);National Natural Science Foundation of China 81902075(to Dongrong Yi);CAMS Innovation Fund for Medical Sciences 2021-I2M-1-038(to Shan Cen);2021-I2M-1-030(to Quanjie Li);2021-I2M-1-043(to Xiaoyu Li).

摘　　要：Type I interferon(IFN)inhibits a wide spectrum of viruses through stimulating the expression of antiviral proteins.As an IFN-induced protein,myxovirus resistance B(MXB)protein was reported to inhibit multiple highly pathogenic human viruses.It remains to be determined whether MXB employs a common mechanism to restrict different viruses.Here,we find that IFN alters the subcellular localization of hundreds of host proteins,and this IFN effect is partially lost upon MXB depletion.The results of our mechanistic study reveal that MXB recognizes vimentin(VIM)and recruits protein kinase B(AKT)to phosphorylate VIM at amino acid S38,which leads to reorganization of the VIM network and impairment of intracellular trafficking of virus protein complexes,hence causing a restriction of virus infection.These results highlight a new function of MXB in modulating VIM-mediated trafficking,which may lead towards a novel broad-spectrum antiviral strategy to control a large group of viruses that depend on VIM for successful replication.

关 键 词：MXB VIMENTIN Broad antiviral strategy Cytoskeleton network AKT 

分 类 号：R96[医药卫生—药理学]