山茱萸中的一个新联苯类木脂素  

A new biphenyl lignan from Cornus officinalis

作　　者：杨梦[1,2] 郝志友 王小兰[1,3] 周诗琪 肖超远[1,2] 张俊阳 郑晓珂 冯卫生 YANG Meng;HAO Zhi-you;WANG Xiao-lan;ZHOU Shi-qi;XIAO Chao-yuan;ZHANG Jun-yang;ZHENG Xiao-ke;FENG Wei-sheng(School of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450046,China;The Engineering and Technology Research Center for Chinese Medicine Development of Henan Province,Zhengzhou 450046,China;Academy of Chinese Medical Sciences,Henan University of Chinese Medicine,Zhengzhou 450046,China;Co-construction of Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan&Education Ministry,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学药学院,河南郑州450046 [2]河南省中药开发工程技术研究中心,河南郑州450046 [3]河南中医药大学中医科学院,河南郑州450046 [4]呼吸疾病中医药防治省部共建协同创新中心,河南郑州450046

出　　处：《药学学报》2024年第6期1751-1756,共6页Acta Pharmaceutica Sinica

基　　金：中央引导地方科技发展专项资金([2016]149);河南省科技攻关项目(212102311091);河南省高层次人才特殊支持计划(ZYQR201810080).

摘　　要：采用大孔吸附树脂、MCI、Toyopearl HW-40C以及硅胶等柱色谱技术并结合半制备液相对山茱萸水提物进行分离纯化,通过HRESIMS、NMR、IR、UV和ECD等方法对分离得到的化合物进行结构鉴定。从山茱萸果实中共分离得到12个化合物,分别鉴定为neolignan B(1)、2,3-dihydro-7-methoxy-2-(4′-hydroxy-3′-methoxyphenyl)-3a-O-β-D-xylopyranosyloxymethyl-5-benzofuranpropanol(2)、cornucadinoside A(3)、3,4-二羟基苯乙酮(4)、没食子酸正丁酯(5)、间羟基苯甲酸(6)、奎宁酸正丁酯(7)、5-羟基麦芽酚(8)、2-糠酸(9)、5-羟甲基糠醛(10)、5-(甲氧基羰基)-2-吡咯烷酮(11)、苹果酸二甲酯(12)。化合物1为新联苯类木脂素,命名为neolignan B。化合物2、4、5、7~9、11为首次从山茱萸中分离得到。Macroporous adsorption resin,MCI,Toyopearl HW-40C and silica gel column chromatography combined with the semi-preparative HPLC were used to isolate and purify the water extract of Cornus officinalis.And the structures of compounds were identified by HRESIMS,NMR,IR,UV and ECD.A total of twelve compounds were isolated from the fruits of Cornus officinalis.They were identified as neolignan B(1),2,3-dihydro-7-methoxy-2-(4′-hydroxy-3′-methoxyphenyl)-3a-O-β-D-xylopyranosyloxymethyl-5-benzofuranpropanol(2),cornucadinoside A(3),3,4-dihydroxyacetophenone(4),n-butyl gallate(5),3-hydroxybenzoic acid(6),n-butyl quininate(7),5-hydroxymaltol(8),2-furolic acid(9),5-hydroxymethylfurfural(10),5-(methoxycarbonyl)-2-pyrrolidone(11),and dimethyl malate(12).Compound 1 is a new biphenyl lignan,named as neolignan B.Compounds 2,4,5,7−9 and 11 were isolated from Cornus officinalis for the first time.

关 键 词：山茱萸 化学成分 neolignan B 联苯类木脂素 分离鉴定 

分 类 号：R284[医药卫生—中药学]