不孕症合并中枢性闭经的诊治思考  

Thoughts on diagnosis and treatment of infertil⁃ity with hypothalamic-pituitary amenorrhea.

作　　者：郁琦[1] 李小卉 YU Qi;LI Xiao-hui(Department of Obstetrics and Gynecology,National Clinical Research Center for Obstetrics&Gynecologic Diseases,Peking Union Medical College Hospital,Chinese Academy of Medi-cal Sciences&Peking Union Medical College,Bei-jing 100730,China)

机构地区：[1]中国医学科学院北京协和医学院北京协和医院妇产科国家妇产疾病临床医学研究中心,北京100730

出　　处：《中国实用妇科与产科杂志》2024年第6期580-583,共4页Chinese Journal of Practical Gynecology and Obstetrics

基　　金：国家重点研发计划(2022YFC2703802)。

摘　　要：中枢性闭经,即下丘脑-垂体功能障碍所致的闭经,以低促性腺激素性性腺功能减退为特征。这类患者通常因慢性无排卵、雌激素水平低下而面临不孕的问题。通过激素补充治疗、生活方式管理及辅助生殖技术可使之获得较好的排卵率和妊娠结局。其中根据中枢性闭经的具体原因及患者的自身情况进行个体化的管理尤为重要。文章从中枢性闭经的诊断、备孕和治疗方面探讨不孕症合并中枢性闭经的诊治。Hypothalamic-pituitary amenorrhea,re⁃sulting from hypothalamic-pituitary dysfunction,is characterized by hypogonadotropic hypogonadism.Patients typically face infertility issues due to chronic anovulation and low estrogen level.Ovulation rate and pregnancy outcome can be achieved through hormone replacement,lifestyle management,and assisted re⁃productive technology.Individualized management is especially important.This article explores the diagnosis,preconception care,and treatment aspects related to infertility associated with hypothalamic-pituitary amenorrhea.

关 键 词：中枢性闭经 低促性腺激素性性腺功能减退 垂体功能低下 不孕症 

分 类 号：R711.6[医药卫生—妇产科学]