不孕症合并卵巢源性内分泌功能肿瘤的诊治  

Diagnosis and treatment of infertility with ovari⁃an-derived endocrine tumors.

作　　者：张婉玉 邓成艳[1] ZHANG Wan-yu;DENG Cheng-yan(Centre of Gynecological Endocri-nology&Assisted Reproduction,National Clinical Research Center for Obstetric&Gynecologic Diseas-es,State Key Laboratory of Complex Severe&Rare Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医学院、北京协和医院妇科内分泌与生殖中心、疑难重症及罕见病国家重点实验室、国家妇产疾病临床医学研究中心,北京100730

出　　处：《中国实用妇科与产科杂志》2024年第6期623-625,共3页Chinese Journal of Practical Gynecology and Obstetrics

基　　金：中央高水平医院临床科研专项项目(2022-PUMCH-B-080,2022-PUMCH-C-64)。

摘　　要：卵巢源性内分泌功能肿瘤主要包括性索-间质肿瘤(SCST)、卵巢类固醇细胞瘤(SCT)及卵巢生殖细胞肿瘤(OGCT)。因其干扰正常生殖内分泌轴,可导致排卵障碍,故与不孕症密切相关。该类女性患者往往因性早熟、或性腺功能异常、或男性化、或月经紊乱、或原发性/继发性闭经及不孕症就诊,需要结合临床症状、性激素实验室检查及影像学检查(超声或磁共振成像)判断,通过手术切除占位性病变,依靠病理学确诊。术后如果仍然不孕,应选择恰当的助孕方式。Ovarian-derived endocrine tumors mainly include ovarian sex cord-stromal tumor(SCST),ovarian steroid cell tumor(SCT),and ovarian germ cell tumor(OGCT).It interferes with the normal repro⁃ductive endocrine axis,leading to ovulation disorders,which is closely related to infertility.Such patients often present for precocious puberty,gonadal dysfunction,virilization,menstrual disorder,primary/secondary amenorrhea and infertility,which need to be judged by clinical symptoms,sex hormone tests and imaging examination(ultrasound or MRI),the tumor should be removed by surgery,and the diagnosis is confirmed by pathology.After surgery,if still infertile,choose the appropriate way to assist pregnancy.

关 键 词：不孕症 卵巢性索-间质肿瘤 卵巢类固醇细胞瘤 卵巢生殖细胞肿瘤 

分 类 号：R711.5[医药卫生—妇产科学]