中药活性成分抑制哺乳动物雷帕霉素靶蛋白(mTOR)通路抗肿瘤作用的研究进展  

Progress on anti-tumor effects of active ingredients in traditional Chinese medicine inhibiting mammalian target of rapamycin(mTOR)pathway

作　　者：王渝 张恒[2] 王华庆[2] 王辉[2] WANG Yu;ZHANG Heng;WANG Huaqing;WANG Hui(Graduate School,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Department of Oncology,Tianjin Union Medical Center,Tianjin 300121,China)

机构地区：[1]天津中医药大学研究生院,天津301617 [2]天津市人民医院肿瘤诊治中心,天津300121

出　　处：《现代药物与临床》2024年第5期1337-1342,共6页Drugs & Clinic

基　　金：国家自然科学基金面上项目(81972847);天津市自然科学基金多元投入基金资助项目(21JCYBJC01830);天津市医学重点学科(专科)建设项目资助(TJYXZDXK-053B);天津市人民医院院级课题(2022ZLXK01,2022ZLXK07)。

摘　　要：哺乳动物雷帕霉素靶蛋白(m TOR)与癌症有密切关系,抑制m TOR通路可以发挥抗肿瘤作用。目前许多m TOR抑制剂被开发用于癌症的治疗。一些中药活性成分如蒽醌类、生物碱类、萜类、多糖类、黄酮类、多酚类成分可以通过抑制m TOR通路诱导肿瘤细胞凋亡、促进自噬、阻断细胞周期发挥抗肿瘤作用。总结了中药活性成分抑制m TOR通路抗肿瘤作用的研究进展,明确其作用机制,为临床应用提供参考。Mammalian target of rapamycin(mTOR)is closely related to cancer,and inhibiting the mTOR pathway can exert anti-tumor effects.At present,many mTOR inhibitors are being developed for the treatment of cancer.Some active ingredients in traditional Chinese medicine,such as anthraquinone,alkaloids,terpenoids,polysaccharides,flavonoids,polyphenols,can exert anti-tumor effects by inhibiting the mTOR pathway through inducing tumor cell apoptosis,promoting autophagy,and blocking the cell cycle.This article summarizes the research progress on anti-tumor effects of active ingredients in traditional Chinese medicine through the mTOR pathway,clarifies their mechanisms of action,and provides reference for clinical applications.

关 键 词：蒽醌 生物碱 萜类 多糖 黄酮 多酚 哺乳动物雷帕霉素靶蛋白信号通路 抗肿瘤作用 

分 类 号：R285[医药卫生—中药学] R972[医药卫生—中医学]