β-榄香烯治疗结直肠癌作用机制研究进展  

Progress on mechanism of β-elemene in treatment of colorectal cancer

作　　者：孙清秀 蒲凤华 SUN Qingxiu;PU Fenghua(Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China;Nanbu County People’s Hospital,Nanchong 637300,China)

机构地区：[1]川北医学院附属医院,四川南充637000 [2]南部县人民医院,四川南充637300

出　　处：《现代药物与临床》2024年第5期1354-1359,共6页Drugs & Clinic

基　　金：吴阶平医学基金会临床科研专项(HK8203521)。

摘　　要：结直肠癌具有较高的发病率和病死率,药物治疗可延长生存期,但会出现不同程度的耐药。β-榄香烯是从温郁金中提取的活性成分,具有广谱的抗肿瘤活性,可抑制肿瘤细胞生长和增殖、诱导肿瘤细胞凋亡、抑制肿瘤细胞侵袭和转移、逆转肿瘤药物耐药、联合化疗增效减毒、同步放疗增敏、改善免疫功能。综述了β-榄香烯治疗结直肠癌的作用机制研究进展,以期为β-榄香烯临床治疗结直肠癌提供参考。Colorectal cancer has a high incidence rate and mortality.Drug treatment can prolong the survival period of patients,but there will be different degrees of drug resistance.β-Elemene is an active ingredient extracted from Curcumae Radix,which has a broadspectrum anti-tumor activity.It can inhibit the growth and proliferation of tumor cells,induce tumor cell apoptosis,inhibit tumor cell invasion and metastasis,reverse tumor drug resistance,enhance the efficacy and toxicity of combined chemotherapy,increase sensitization with simultaneous radiotherapy,and improve immunization.This article provides an overview of research progress on mechanism ofβ-elemene in treatment of colorectal cancer,hoping to provide reference forβ-elemene in clinical treatment of colorectal cancer.

关 键 词：Β-榄香烯 结直肠癌 细胞凋亡 细胞侵袭 耐药 增敏 免疫 

分 类 号：R285[医药卫生—中药学]