大黄素防治动脉粥样硬化作用机制的研究进展  

Research progress on mechanism of emodin in prevention and treatment of atherosclerosis

作　　者：蔡箫杨 张丽敏 肖寒 CAI Xiaoyang;ZHANG Limin;XIAO Han(Department of Cardiovascular Medicine,The Second Affiliated Clinical Medical College of the Army Medical University,Chongqing 400037,China)

机构地区：[1]陆军军医大学附属第二临床医学院心血管内科,重庆400037

出　　处：《现代药物与临床》2024年第5期1360-1364,共5页Drugs & Clinic

摘　　要：心血管疾病已成为威胁人类健康的最主要疾病,其中动脉粥样硬化是心血管疾病的主要原因和病理基础。大黄素是从大黄、虎杖中获得的蒽醌衍生物,具有多种药理作用。大黄素可通过降低炎症反应、降低氧化应激反应、调节脂质代谢、阻止血管平滑肌增殖、保护血管内皮功能、稳定动脉粥样硬化斑块等多种途径对动脉粥样硬化发挥防治作用。综述了大黄素防治动脉粥样硬化的作用机制研究进展,为大黄素防治动脉粥样硬化的临床应用提供参考。Cardiovascular disease has become the most important disease threatening human health,and atherosclerosis is the main cause and pathological basis of cardiovascular disease.Emodin is an anthraquinone derivative obtained from Rhei Radix et Rhizoma and Polygoni Cuspidati Rhizoma,which has various pharmacological effects.Emodin can prevent and treat atherosclerosis by reducing inflammatory reaction,reducing oxidative stress reaction,regulating lipid metabolism,preventing vascular smooth muscle proliferation,protecting vascular endothelial function,stabilizing atherosclerotic plaque.This article reviews the research progress of mechanism of emodin in prevention and treatment of atherosclerosis,which provides a reference for the clinical application of emodin in prevention and treatment of atherosclerosis.

关 键 词：大黄素 动脉粥样硬化 炎症反应 氧化应激 脂质代谢 血管平滑肌增殖 血管内皮功能 动脉粥样硬化斑块 

分 类 号：R285[医药卫生—中药学] R973[医药卫生—中医学]