基于线粒体功能探讨从“玄府-络脉-脏腑”论治心力衰竭  

Discussion on the Treatment of Heart Failure from the Theory of"Sweat Pore-Collaterals-Zang and Fu Organs"Based on Mitochondrial Function

作　　者：李宇轩 汪吴娇 李鹏[1] 张园园 李星星 夏君彦 冯汝丽 李冬 林谦 李岩 LI Yuxuan;WANG Wujiao;LI Peng;ZHANG Yuanyuan;LI Xingxing;XIA Junyan;FENG Ruli;LI Dong;LIN Qian;LI Yan(Beijing University of Chinese Medicine,Beijing,100029;Dongzhimen Hospital,Beijing University of Chinese Medicine;The Affiliated Hospital of Shaanxi University of Chinese Medicine;Dongfang Hospital,Beijing University of Chinese Medicine)

机构地区：[1]北京中医药大学,北京市100029 [2]北京中医药大学东直门医院 [3]陕西中医药大学附属医院 [4]北京中医药大学东方医院

出　　处：《中医杂志》2024年第13期1346-1352,共7页Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(81973622);北京市卫生健康委员会首都卫生发展科研专项(首发2020-2-4201)。

摘　　要：线粒体是心肌细胞能量代谢的主要场所,同时介导细胞凋亡及免疫反应,线粒体功能障碍与心力衰竭的发生发展密切相关。结合线粒体功能障碍在心力衰竭发病中的作用机制,提出线粒体功能与“玄府-络脉-脏腑”类似,据此从“玄府-络脉-脏腑”论治心力衰竭,认为心力衰竭的核心病机为气虚,气虚则玄府开阖无力,甚至玄府闭密,致气虚血瘀,络脉瘀滞不荣,气血津液则无法渗灌充养脏腑,心失所养,发为本病。治疗应以益气开玄、辛以通络、活血利水为法,用药以益气、活血、利水类药物为主。Mitochondria are the main site of energy metabolism in cardiomyocytes,and at the same time mediate apoptosis and immune response,so mitochondrial dysfunction is closely related to the development of heart failure.Combined with the pathogenesis of mitochondrial dysfunction and heart failure,it is proposed that the mitochondrial function is similar to"sweat pore-collaterals-zang and fu organs",according to which the treatment of heart failure is based on the theory of"sweat pore-collaterals-zang and fu organs".It is believed that the core mechanism of heart failure is qi deficiency,and qi deficiency leads to the weakness of the sweat pore opening and closing,or even the sweat pore closure,then resulting in qi deficiency and blood stasis,collaterals stagnation fail to flourish,and qi,blood,and body fluids can not infiltrate and nourish zang-fu organs,so that the heart fail to be nourished,and the dis⁃ease will develop.The treatment should be based on the method of boosting qi and opening sweat pore,using acridity to unblock the collaterals,and invigorating blood and draining water,with medicinal of boosting qi,invigorating blood,and draining water as treatment.

关 键 词：心力衰竭 线粒体 玄府 络脉 脏腑 

分 类 号：R259[医药卫生—中西医结合]