1221例女性基础性激素水平及抗苗勒管激素水平不同年龄段变化特征——女子“以七为期”的生殖衰老规律回顾性研究  

Characteristics of Basal Sex Hormone Levels and Anti-müllerian Hormone Levels in 1221 Women of Different Ages:A Retrospective Study on the Law of Women Reproductive Aging in the"Seven-year Period"Theory

作　　者：梁婉诗 廖怡茹 付靖涵 胡罗丹 杨洪艳[3] 刘建[3] 成芳平[3] 聂广宁[3] LIANG Wanshi;LIAO Yiru;FU Jinghan;HU Luodan;YANG Hongyan;LIU Jian;CHENG Fangping;NIE Guangning(The Second Clinical Medical College of Guangzhou University of Chinese Medicine,Guangzhou,510405;Zhongjing Academy,School of Traditional Chinese Medicine,Henan University of Chinese Medicine;The Second Affiliated Hospital of Guangzhou University of Chinese Medicine/Guangdong Provincial Hospital of Traditional Chinese Medicine)

机构地区：[1]广州中医药大学第二临床医学院,广东省广州市510405 [2]河南中医药大学中医学院仲景书院 [3]广州中医药大学第二附属医院/广东省中医院

出　　处：《中医杂志》2024年第13期1369-1374,共6页Journal of Traditional Chinese Medicine

基　　金：广东省基础与应用基础研究基金(2021A1515220139);广东省自然科学基金(2022A1515011651);广东省省部共建中医湿证国家重点实验室开放课题(SZ2021KF06);广东省中医药拔尖人才科研专项(BJ2022KY09);2019年度广东省中医院中医药科学技术研究专项(YN2019ML04);广州市科技局项目(2024A03J0728)。

摘　　要：目的从基础性激素水平及抗苗勒管激素水平不同年龄段变化特征探析中医理论中女子“以七为期”的生殖衰老规律。方法回顾性收集2018年1月至2022年12月于广东省中医院就诊并行基础性激素及抗苗勒管激素水平检测的女性就诊者数据资料,根据不同年龄段分为一七/二七组(21岁以下)、三七组(21~27岁)、四七组(28~34岁)、五七组(35~41岁)、六七组(42~48岁)及七七及以后组(49岁及以上)。收集就诊者年龄、平均月经周期(近3个月),基础性激素[包括卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、睾酮(T)]水平及FSH/LH值,抗苗勒管激素(AMH)水平,比较各组数据资料中各指标的变化情况。结果共纳入数据资料1221份。各组总体上FSH、LH、FSH/LH值、E2、T、AMH水平及平均月经周期差异均有统计学意义(P<0.05或P<0.01)。三七组的AMH出现峰值。与三七组相比,四七组FSH/LH值升高,LH、AMH和T水平下降,月经周期缩短(P<0.01)。五七组FSH/LH值继续升高,LH、AMH、T水平继续下降,月经周期继续缩短,FSH和E2水平开始升高(P<0.05或P<0.01)。与五七组比较,六七组FSH、LH、E2水平均升高,AMH、T水平继续降低(P<0.05或P<0.01)。与六七组比较,七七及以后组FSH、LH水平继续升高,AMH、E2水平下降(P<0.01)。结论女子“以七为期”的生殖衰老规律与不同年龄段基础性激素水平及抗苗勒管激素水平变化特征基本相符,其中“三七”阶段生殖能力达到峰值,“四七”阶段开始逐渐走向生殖衰老。Objective To explore the law of women reproductive aging based on theory of"seven-year period"in traditional Chinese medicine(TCM)through analyzing the characteristics of basic sex hormone levels and anti-müllerian hormone levels in women of different ages.Methods The data of female who visited Guangdong Provincial Hospital of Traditional Chinese Medicine from January 2018 to December 2022 and accepted basic hormone and anti-müllerian hormone determination were collected retrospectively.According to the age of subjects,they were divided into the"1-2 seven"group(under 21 years old),"3 seven"group(21-27 years old),"4 seven"group(28-34 years old),"5 seven"group(35-41 years old),"6 seven"group(42-48 years old)and"7 seven"and older group(49 years old and above).The age,average menstrual cycle in the past 3 months,basic hormone levels including follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2),testosterone(T)and FSH/LH value,and anti-müllerian hormone(AMH)levels were collected and compared.Results A total of 1221 cases were included.The differences in FSH,LH,FSH/LH values,E2,T,AMH levels and average menstrual cycle among the groups were statistically significant(P<0.05 or P<0.01).AMH peaked in the"3 seven"group.Compared to those in the"3 seven"group,the FSH/LH value in the"4 seven"group increased,while the LH,AMH and T levels decreased,and the menstrual cycle was shortened(P<0.01).The FSH/LH,LH,AMH,T and menstrual cycle in the"5 seven"group were consistent with the changing trend of those in the"4 seven"group,while the FSH and E2 levels in the"5 seven"group were significantly higher(P<0.05 or P<0.01).Compared to those in the"5 seven"group,the FSH,LH and E2 levels of the"6 seven"group increased,and the AMH and T levels continued to decrease(P<0.05 or P<0.01).Compared to those in the"6 seven"group,the FSH and LH levels of the"7 seven"and older group continued to increase,and the AMH and E2 levels decreased(P<0.01).Conclusion The law of women reproductive aging in the"seven-year period"theory is b

关 键 词：性激素 抗苗勒管激素 生殖衰老 女性 以七为期 回顾性研究 

分 类 号：R271[医药卫生—中医妇科学]