宿主免疫与HIV相关隐球菌性脑膜炎预后研究进展  

Advances in the host immunity and prognosis of HIV-associated cryptococcal meningitis

作　　者：赵树伟 苏瑞[1] 李钰春 董天祥[1] 李玉叶[1] 李红宾[1] ZHAO Shuwei;SU Rui;LI Yuchun;DONG Tianxiang;LI Yuye;LI Hongbin(Department of Dermatology,First Affiliated Hospital of Kunming Medical University,Kunming,China,650031;Class of 2021 Clinical Medicine major,2.Haiyuan college of Kunming Medical University,Kunming,China,650106)

机构地区：[1]昆明医科大学第一附属医院皮肤科,云南昆明650032 [2]昆明医科大学海源学院,云南昆明650106

出　　处：《皮肤病与性病》2024年第3期168-171,共4页Dermatology and Venereology

基　　金：云南省科技厅-昆明医科大学联合基金重点项目(202101AY070001-022);云南省高层次人才培养支持计划名医专项(YNWR-MY-2019-026);云南省科技厅面上项目(202201AT070327);云南省防治艾滋病局项目;云南省皮肤与免疫性疾病临床医学中心(ZX2019-03-02)。

摘　　要：即使在全球开展抗逆转录病毒治疗和抗真菌药物治疗背景下,HIV相关隐球菌性脑膜炎仍然是艾滋病患者死亡的重要原因。宿主免疫状态是决定HIV相关隐球菌性脑膜炎预后的关键因素,近年来宿主免疫与HIV相关隐球菌性脑膜炎预后相关性的研究取得一些进展,本文就宿主先天免疫、适应性免疫、中枢神经系统免疫及免疫重建综合征对HIV相关隐球菌性脑膜炎预后的影响进行综述。Even in the context of global antiretroviral and antifungal therapy,HIV-associated cryptococcal meningitis remains an main cause of death in people with AIDS.Host immunity status is a key factor in determining the prognosis of HIV-associated cryptococcal meningitis.In recent years,some progress has been made in the study of the correlation between host immunity and the prognosis of HIVassociated cryptococcal meningitis.In this review,the host innate immunity,adaptive immunity,central nervous system immunity and immune reconditioning syndrome on the prognosis of HIV-associated cryptococcal meningitis are reviewed.

关 键 词：HIV相关隐球菌性脑膜炎 先天免疫 适应性免疫 中枢神经系统免疫 免疫重建综合征 

分 类 号：R512.91[医药卫生—内科学] R519.4[医药卫生—临床医学]