Association between plasma growth differentiation factor 15 levels and pre-eclampsia in China  

作　　者：Shuhong Xu Yicheng Lu Mengxin Yao Zhuoqiao Yang Yan Chen Yaling Ding Yue Xiao Fei Liang Jiani Qian Jinchun Ma Songliang Liu Shilan Yan Jieyun Yin Qiuping Ma 

机构地区：[1]Taicang Affiliated Hospital of Soochow University,The First People's Hospital of TaiCang,Soochow University,Suzhou,Jiangsu,China [2]Department of Epidemiology and Health Statistic,Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non-communicable Diseases,Suzhou Medical College of Soochow University,Suzhou,Jiangsu,China [3]Changshu Hospital Affiliated to Nanjing University of Chinese Medicine,Suzhou,Jiangsu,China [4]Department of Chronic Disease,Gusu Center for Disease Control and Prevention,Suzhou,Jiangsu,China [5]Huzhou First People's Hospital,Huzhou,Zhejiang,China

出　　处：《Chronic Diseases and Translational Medicine》2024年第2期140-145,共6页慢性疾病与转化医学（英文版）

基　　金：2022 guiding project of the 28 thbatch of Suzhou Science and Technology Development Plan(Medical and Health Scientific and Technological Innovation),Grant/Award Number:SKYD2022061;2021 Taicang Basic Research Program(Medical and Health Applied Basic Research Project),Grant/Award Number:TC2021JCYL03;National Natural Science Foundation of China,Grant/Award Number:82273635。

摘　　要：Background Growth differentiation factor-15(GDF-15)is a stress response protein and is related to cardiovascular diseases(CVD).This study aimed to investigate the association between GDF-15 and pre-eclampsia(PE).Method The study involved 299 pregnant women,out of which 236 had normal pregnancies,while 63 participants had PE.Maternal serum levels of GDF-15 were measured by using enzyme-linked immunosorbent assay kits and then translated into multiple of median(MOM)to avoid the influence of gestational week at blood sampling.Logistic models were performed to estimate the association between GDF-15 MOM and PE,presenting as odd ratios(ORs)and 95%confidence intervals(CIs).Results MOM of GDF-15 in PE participants was higher compared with controls(1.588 vs.1.000,p<0.001).In the logistic model,pregnant women with higher MOM of GDF-15(>1)had a 4.74-fold(95%CI=2.23–10.08,p<0.001)increased risk of PE,adjusted by age,preconceptional body mass index,gravidity,and parity.Conclusions These results demonstrated that higher levels of serum GDF-15 were associated with PE.GDF-15 may serve as a biomarker for diagnosing PE.

关 键 词：growth differentiation factor 15 macrophage inhibiting cytokine 1 PRE-ECLAMPSIA 

分 类 号：R714.244[医药卫生—妇产科学]