子宫腺肌病转录组学研究进展  

Research progress of transcriptomic study in adenomyosis

作　　者：汤卓颖 刁飞扬[1] Tang Zhuoying;Diao Feiyang(Reproductive Medicine Center,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学第一附属医院生殖医学中心,南京210029

出　　处：《中华生殖与避孕杂志》2024年第5期531-536,共6页Chinese Journal of Reproduction and Contraception

基　　金：国家重点研发计划(2022YFC2702500)。

摘　　要：子宫腺肌病是一种常见的妇科疾病,临床表现主要为盆腔疼痛、异常子宫出血和生殖障碍,目前尚无统一的评估标准及治疗方案,因此了解子宫腺肌病相关的分子机制至关重要。转录组学从整体水平解释了基因组的功能元件,揭示了特定生物学过程中的分子机制。近年来,随着转录组学研究技术飞速发展,已有多项研究基于转录组学探讨了子宫腺肌病病理生理机制,识别了子宫腺肌病的生物标志物和潜在治疗靶点,为子宫腺肌病的诊断及治疗提供了新视角。本文就转录组测序技术在子宫腺肌病中的应用研究进展进行综述。Adenomyosis is a common gynecological disease with the main clinical manifestations of pelvic pain,abnormal uterine bleeding and reproductive disorders.At present,there is no unified evaluation criteria and treatment plan for adenomyosis,so it is important to understand the molecular mechanism of adenomyosis.Transcriptomics explains the functional elements of the genome at a global level and reveals the molecular mechanisms in specific biological processes.In recent years,with the rapid development of transcriptomics analysis technology,a number of studies have explored the molecular mechanism of adenomyosis based on transcriptomics,identified biomarkers and potential therapeutic targets of adenomyosis,and provided a new perspective for the diagnosis and treatment of adenomyosis.This review focuses on the latest research advances in transcriptome analysis in adenomyosis.

关 键 词：子宫腺肌病 转录组学 微阵列 RNA测序 单细胞RNA测序 子宫内膜容受性阵列 

分 类 号：R711.71[医药卫生—妇产科学]