巨噬细胞抗单纯疱疹病毒1型感染作用机制的研究进展  

Progress in research on action mechanism of macrophages against herpes simplex virus type 1 infection

作　　者：张振潇(综述) 李琦涵(审校)[1] ZHANG Zhenxiao;LI Qihan(Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases,Institute of Medical Biology,Chinese Academy of Medical Science&Peking Union Medical College,Kunming 650118,Yunnan Province,China)

机构地区：[1]中国医学科学院北京协和医学院医学生物学研究所、云南省重大传染病疫苗研发重点实验室,云南昆明650118

出　　处：《中国生物制品学杂志》2024年第6期763-768,共6页Chinese Journal of Biologicals

基　　金：国家自然科学基金(82171817);云南省自然科学基金(2020-01AUO70142)。

摘　　要：单纯疱疹病毒1型(herpes simplex virus type 1,HSV-1)是一种具有免疫逃逸、潜伏以及再感染能力的DNA病毒。尽管其生物学特性已被广泛研究,但目前尚未开发出专门针对HSV-1的治疗药物和预防性疫苗。HSV-1的感染能够引发宿主固有免疫和适应性免疫响应。其中,巨噬细胞通过病原体的吞噬、加工和提呈等过程,在抗病毒免疫反应中发挥着重要作用。本文对巨噬细胞在对抗HSV-1感染中作用的最新研究进展作一综述,以期为未来的疫苗设计和药物研发提供参考。Herpes simplex virus type 1(HSV-1)is a DNA virus renowned for its ability to evade the immune response,establish latency,and reinfect.Despite extensive research into its biological characteristics,there are no specific therapeutics or preventative vaccines currently available for HSV-1.Infection with HSV-1 triggers innate and adaptive immune responses in the host,with macrophages playing a crucial role in antiviral immune responses through processes such as pathogen engulfment,processing,and presentation.This review aims to elucidate the latest research developments on the role of macrophages in combating HSV-1 infection,in hopes of providing insights for future vaccine design and drug development.

关 键 词：单纯疱疹病毒 巨噬细胞 药物 疫苗 

分 类 号：R392.1[医药卫生—免疫学]