A New Approach for the Determination of Metronidazole Using Switchable Solvent Coupled with Au-MWCNTs-Modified Electrochemical Sensor  

作　　者：Siamak Kiani Shahvandi Mehrorang Ghaedi Hamid Ahmar 

机构地区：[1]Chemistry Department,Yasouj University,Yasouj,75918-74831,Iran [2]Chemistry Department,University of Zabol,Zabol,98615-538,Iran

出　　处：《Journal of Analysis and Testing》2024年第2期191-200,共10页分析检测（英文）

基　　金：financial support for this work provided by Yasouj University Research Council。

摘　　要：In this work,a new liquid-phase microextraction method coupled with an electrochemical technique using a switchable solvent was proposed for the determination of metronidazole.The extraction solvent used was dipropylamine(DPA),which exhibited switchable hydrophilicity.This means that it can become miscible or immiscible when in contact with carboxylic acids in the aqueous sample.The metronidazole was then measured using a glassy carbon electrode that was modified with Au-multiwalled carbon nanotubes(MWCNTs).The eff ect of diff erent parameters such as the type and amount of trigger,the addition of salt,and the volume of extraction solvent on the e fficiency of switchable hydrophilic solvent-based liquid-phase microextraction(SHS-LPME)was investigated using the one-factor-at-a-time method.After optimizing the conditions,the linear calibration curve was obtained in the concentration range of 0.005–250μmol/L.Accordingly,the limit of quantification(LOQ)of 0.005μmol/L and the limit of detection(LOD)of 0.0015μmol/L were obtained,respectively.

关 键 词：Switchable solvent METRONIDAZOLE Liquid-phase microextraction Electrochemical techniques 

分 类 号：O657.1[理学—分析化学] TP212.2[理学—化学] R927.1[自动化与计算机技术—检测技术与自动化装置]