Immune functions of C-type lectins in medical arthropods  

作　　者：Zhihao Ming Zhiqiang Chen Hao Tong Xia Zhou Tingting Feng Jianfeng Dai 

机构地区：[1]Institute of Biology and Medical Sciences,Jiangsu Key Laboratory of Infection and Immunity,Soochow University,Suzhou,Jiangsu Province,China [2]School of Biology and Basic Medical Science,Suzhou Medical College of Soochow University,Suzhou,Jiangsu Province,China

出　　处：《Insect Science》2024年第3期652-662,共11页昆虫科学（英文版）

基　　金：supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions,National Natural Science Foundation of China(81271792,81471571,81971917,and 32170142);Jiangsu Natural Science Foundation(BK20211310).

摘　　要：C-type lectins(CTLs)are a family of proteins that contain 1 or more carbohydrate-recognition domains(CRDs)and bind to a broad repertoire of ligands in the presence of calcium ions.CTLs play important roles in innate immune defenses against microorganisms by acting as pattern-recognition receptors(PRRs)for invading pathogens,such as bacteria,viruses,and parasites.After binding to pathogen-associated ligands,CTLs mediate immune responses,such as agglutination,phagocytosis,and the activation of phenol oxidase progenitors,thereby clearing pathogens.CTLs are an evolutionarily conserved family found in almost all vertebrates and invertebrates.Medical arthropods can acquire and transmit a range pathogens through various approaches,such as bloodsucking,lancing,and parasitism,thus infecting humans and animals with related diseases,some of which can be life-threatening.Recent studies have shown that lectins are important components of the arthropod immune system and are essential for the immune responses of arthropods to arthropod-borne pathogens.This article reviews the current understanding of the structure,function,and signaling pathways involved in CTLs derived from important medical arthropods.

关 键 词：ARTHROPOD C-type lectin innate immunity vector-borne disease 

分 类 号：Q96[生物学—昆虫学]