Research progress toward the influence of mosquito salivary proteins on the transmission of mosquito-borne viruses  

作　　者：Zhao-Yang Wang Kai-Xiao Nie Ji-Chen Niu Gong Cheng 

机构地区：[1]Tsinghua University-Peking University Joint Center for Life Sciences,School of Medicine,Tsinghua University,Bejing,China [2]Institute of Infectious Diseases,Shenzhen Bay Laboratory,Shenzhen,Guangdong,China [3]Department of Pathogen Biology,School of Basic Medicine,Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan,China

出　　处：《Insect Science》2024年第3期663-673,共11页昆虫科学（英文版）

基　　金：supported by the grants from the National Key Research and Development Plan of China(2021YFC2300200,2020YFC1200104,and 2018YFA0507202);The National Natural Science Foundation of China(32188101,31825001,81730063,81961160737,and 82102389);Tsinghua University Spring Breeze Fund(2020Z99CFG017);Shenzhen San-Ming Project for prevention and research on vector-borne diseases(SZSM201611064);the Yunnan Cheng gong expert workstation(202005AF150034);Innovation Team Project of Yunnan Science and Technology Department(202105AE160020);Tsinghua-Foshan Innovation Special Fund(2022THFS6124);Young Elite Scientists Sponsorship Program(2021QNRC001).

摘　　要：Mosquito-borne viruses(MBVs)are a large class of viruses transmitted mainly through mosquito bites,including dengue virus,Zika virus,Japanese encephalitis virus,West Nile virus,and chikungunya virus,which pose a major threat to the health of people around the world.With global warming and extended human activities,the incidence of many MBVs has increased significantly.Mosquito saliva contains a variety of bioactive protein components.These not only enable blood feeding but also play a crucial role in regulating local infection at the bite site and the remote dissemination of MBVs as well as in remodeling the innate and adaptive immune responses of host vertebrates.Here,we review the physiological functions of mosquito salivary proteins(MSPs)in detail,the influence and the underlying mechanism of MSPs on the transmission of MBVs,and the current progress and issues that urgently need to be addressed in the research and development of MSP-based MBV transmission blocking vaccines.

关 键 词：immune response mosquito-borne virus mosquito salivary protein saliva vaccine TRANSMISSION 

分 类 号：R511[医药卫生—内科学]