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作 者:沈乐成 罗嘉伟 张志凌 张诗按[1,3,4] Shen Yuecheng;Luo Jiawei;Zhang Zhiling;Zhang Shian(State Key Laboratory of Precision Spectroscopy,East China Normal University,Shanghai 200241,China;School of Electronics and Information Technology,Sun Yat-Sen University,Guangzhou 510006,Guangdong,China;Collaborative Innovation Center of Extreme Optics,Shanxi University,Taiyuan 030006,Shanxi,China;Joint Research Center of Light Manipulation Science and Photonic Integrated Chip of East China Normal University and Shandong Normal University,State Key Laboratory of Precision Spectroscopy,East China Normal University,Shanghai 200241,China)
机构地区:[1]华东师范大学精密光谱科学与技术国家重点实验室,上海200241 [2]中山大学电子与信息工程学院,广东广州510006 [3]山西大学极端光学协同创新中心,山西太原030006 [4]华东师范大学-山东师范大学光场调控科学与光子芯片器件联合研究中心,华东师范大学精密光谱科学与技术国家重点实验室,上海200241
出 处:《光学学报》2024年第10期264-278,共15页Acta Optica Sinica
基 金:国家自然科学基金(12004446,92150102,12325408,12274129)。
摘 要:光学散射一直以来都被认为是限制光学成像深度的重要因素。近年来,波前整形方法克服光学散射的能力引起了研究人员的广泛关注,其核心思想是通过对入射光进行相位调制,补偿散射引起的波前扰乱。波前整形方法能够有效地重新聚焦散射光,有望实现深层组织内高分辨率成像的目标。回顾了波前整形的历史发展,讨论了不同类型的波前整形方法,展示了其在克服光学散射以实现深层组织成像方面的应用实例,并展望了波前整形方法的未来发展趋势。Significance In biomedical imaging applications,optical scattering disrupts the predictability of the light path,challenging the achievement of high-resolution optical imaging in deep tissue.Even state-of-the-art microscopy is limited to operating at roughly one millimeter in depth using visible light.Overcoming the scattering effect for deep tissue imaging remains a significant challenge.Wavefront shaping methods present a promising solution,allowing researchers to achieve high-resolution imaging through scattering media.By modulating the phase of incident light and compensating for wavefront distortion due to scattering,these methods effectively refocus scattered light,enabling high-resolution imaging in deep tissue.Wavefront shaping methods can be categorized into three types:feedback-based,transmission matrix-based,and optical phase conjugation-based.These methods differ in system complexity and time effectiveness for obtaining the phase map.Feedback-based wavefront shaping,the first successful method for focusing light through scattering media,has a simple setup and low algorithm complexity.Research in this area has focused on improving optimization algorithms to find the optimal phase distribution,enhancing robustness and convergence speed.Transmission matrix-based wavefront shaping models light propagation in a scattering medium by using a linear transmission matrix,enabling wide-field imaging of hidden objects after obtaining the optical transmission matrix.Neural networks excel in manipulating nonlinear scattering and assist in wavefront shaping,particularly in scenarios involving multimode gain fibers and strongly absorbing tissue.Optical phase conjugation-based wavefront shaping is the most efficient method,requiring only a one-time measurement to determine a row vector of the transmission matrix.It efficiently acquires and controls information about the scattered light field,demonstrating advantages in dynamic scattering processes.In applications such as imaging living tissue,where optical scattering
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