基于数据挖掘的《中国药典》中治疗痛经中成药组方规律分析  

Analysis of the composition rules of Chinese patent medicines for dysmenorrhea in Chinese pharmacopoeia based on data mining

作　　者：马笑笑 顾壮壮 王倩[1] 张金保[1,2,3] MA Xiao-xiao;GU Zhuang-zhuang;WANG Qian;ZHANG Jin-bao(Gansu University of Chinese Medicine,Lanzhou 730000,Gansu;Northwest Collaborative Innovation Center for Traditional Chinese Medicine Co-constructed by Gansu Province&MOE of PRC,Lanzhou 730000,Gansu;Gansu Pharmaceutical Industry Innovation Research Institute,Lanzhou 730000,Gansu)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]西北中藏药省部共建协同创新中心,甘肃兰州730000 [3]陇药产业创新研究院,甘肃兰州730000

出　　处：《中药与临床》2024年第2期89-95,共7页Pharmacy and Clinics of Chinese Materia Medica

基　　金：甘肃省自然科学基金项目(20JR10RA330);甘肃省道地药材质量标准化技术研究与推广工程实验室开放基金项目(ddyc-2022-02)。

摘　　要：目的:通过分析2020版《中国药典》治疗痛经中成药的药物配伍规律,为临床合理用药及新组方的研发提供参考。方法:收集并整理2020版《中国药典》中治疗痛经的处方信息,运用Excel 2010对纳入药物的频次、功效、四气、五味、归经等进行数据分析,并用SPSS对数据进行关联规则可视化和聚类分析。结果:纳入中成药处方51个,共150味中药,中药频次排名前3位的为当归、延胡索、白芍;功效以活血化瘀,补虚为主;治疗的痛经证型以气滞血瘀最多,气血虚弱次之;四气五味以温,苦为主,归经以肝为主;关联规则分析得到关联强度最高的药对组合7组,2味药组合为当归-白芍、当归-香附等,3味药组合为香附-延胡索-当归;熟地黄-延胡索-香附等;中药聚类分析得出聚类组合4组。结论:通过对治疗痛经的中成药的频次、性味、主治、归经、分类等进行挖掘分析,揭示了其组方配伍用药特点,阐明了其临床应用规律,可为临床合理治疗痛经及深入研究提供一定参考。Objective:To investigate the medication rule of Chinese patent medicine in the treatment of dysmenorrhea in the 2020 edition of Chinese Pharmacopoeia based on data mining and provide reference for clinical rational drug use and research and development of new formulations.Method:The prescription information for the treatment of dysmenorrhea in the 2020 edition of Chinese Pharmacopoeia was collected and sorted out.Excel 2010 was used to analyze the frequency,function,four properties,five tastes and meridian tropism of the included drugs,and SPSS was used to visualize and cluster the data.Result:A total of 51 Chinese patent medicine prescriptions were included,involving 150 Chinese medicines.The top three Chinese medicine frequency were Danggui,Yanhusuo and Baishao.The main function included promoting blood circulation and removing blood stasis,and tonify deficiency.The most common type of dysmenorrhea syndrome was qi stagnation and blood stasis,followed by qi and blood deficiency.Most Chinese medicines were warm and bitter,and enter the liver meridian.Seven groups of drug pair combinations with the highest association strength were obtained by association rule analysis combinations with the highest correlation strength.Two drug combinations were Danggui-Baishao,and Danggui-Xiangfu etc.Three drug combinations were Xiangfu-Yanhusuo-Danggui and Shudihuang-Yanhusuo-Xiangfu etc.Four categories were obtained by systematic cluster analysis.Conclusion:Through the excavation and analysis of the frequency,property and taste,indications,meridian tropism and classification of Chinese patent medicines for the treatment of dysmenorrhea,the characteristics of their compatibility and medication are revealed,and the clinical application rules are clarified,which can provide some reference for the rational treatment of dysmenorrhea and indepth research.

关 键 词：《中国药典》 中成药 痛经 组方规律 数据挖掘 SPSS Modeler 

分 类 号：R286[医药卫生—中药学]