MmpL蛋白功能及其抑制剂研究进展  

Review on function and inhibitor of mycobacterial MmpL proteins

作　　者：崔嘉伟 豆梁丁 赵西林[1] 王岱[1] Cui Jiawei;Dou Liangding;Zhao Xilin;Wang Dai(Department of Experimental Medicine,State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,Xiamen University,Xiamen 361102)

机构地区：[1]厦门大学分子疫苗学和分子诊断学国家重点实验室,厦门361102

出　　处：《中国抗生素杂志》2024年第6期601-610,共10页Chinese Journal of Antibiotics

基　　金：深圳市科技研发资金(No.JCYJ20220530143409021)。

摘　　要：MmpL(Mycobacterial membrane protein large,MmpL)蛋白是结核分枝杆菌的一类重要外排泵转运蛋白,主要参与底物转运,也能介导耐药发生,是潜在的抗结核靶点。本文从MmpL蛋白的结构与功能、耐药机制、蛋白抑制剂等方面进行综述,旨在为MmpL蛋白的功能研究及分枝杆菌的新药研发提供参考建议。Mycobacterial membrane protein large(MmpL)is an important type of efflux pump transporter in Mycobacterium tuberculosis that involves substrate transport and antibiotic resistance,thus being a potential target for anti-tuberculosis.The structure,function,antibiotic resistance and inhibitors of the MmpL proteins were reviewed with the purpose of providing suggestions for exploration of MmpL function and the development of new antimycobacteria agents.

关 键 词：分枝杆菌 MmpL蛋白 耐药机制 蛋白抑制剂 

分 类 号：Q932[生物学—微生物学] R978.1[医药卫生—药品]