间断时间序列法分析国家集中带量采购政策对胰岛素类药物使用影响  

Analysis of the impact of national centralized procurement policies on the use of insulin using interrupted time series analysis

作　　者：许艺文 王淼 王旭涛 苏红[2] XU Yiwen;WANG Miao;WANG Xutao;SU Hong(China State Institute of Pharmaceutical Industry,Shanghai 201203,China;China National Pharmaceutical Industry Informational Center,Shanghai 200040,China)

机构地区：[1]中国医药工业研究总院,上海201203 [2]中国医药工业信息中心,上海200040

出　　处：《世界临床药物》2024年第6期685-692,共8页World Clinical Drug

摘　　要：目的研究国家集中带量采购政策(以下简称集采)对胰岛素类药物在公立医院中使用的影响。方法采用描述性统计分析和间断时间序列分析,将全国胰岛素集采落地时间为政策干预点,分析2017年Q1(每年4个季度依次简称Q1、Q2、Q3、Q4)至2023年Q3全国样本医院胰岛素类药物销售金额、销售量、日均使用费用在集采前后的变化情况。结果集采后,不同类别胰岛素销量趋势变化不同,二代、外资品牌胰岛素呈下降趋势,三代、国产品牌胰岛素呈现上升趋势;不同类别胰岛素销售金额均降低,日均使用费用均有明显断点且明显下降。结论集采对胰岛素类药物进行有效控费,促进胰岛素的使用迭代,改变品牌使用格局,对减轻患者用药负担作用显著。Objective To investigate the impact of the national centralized procurement policies(referred to as centralized procurement below)on the use of insulin in public hospitals.Methods Using descriptive statistical analysis and interrupted time series analysis,the national implementation of insulin centralized procurement was taken as the policy intervention point to analyze the changes in sales amount,sales volume,and average daily usage cost of insulin in sample hospitals before and after the centralized procurement from 2017 Q1(each year is divided into four quarters,which are commonly referred to as Q1,Q2,Q3,and Q4,respectively)to 2023 Q3.Results After centralized procurement,the sales trend of different types of insulin changed differently,with second-generation and foreign-funded brand insulin showing a downward trend,and third-generation and domestic brand insulin showing an upward trend.The sales amount of different types of insulin decreased,and the average daily use cost had obvious breakpoints and decreased significantly.Conclusion Centralized procurement effectively controlled the costs of insulin,promoted the iteration of insulin use,altered the brand usage landscape,and significantly reduced the drug burden of patients.

关 键 词：间断时间序列 药品集中带量采购 胰岛素 

分 类 号：R95[医药卫生—药学]