细菌中交互敏感性的分子机制及用药策略  

Molecular Mechanisms and Medication Strategies of Collateral Sensitivity in Bacteria

作　　者：吴梦慧 刘方佳 李东华 盛席静 刘泉[1] 戴梦红[1] 吴敏 WU Menghui;LIU Fangjia;LI Donghua;SHENG Xijing;LIU Quan;DAI Menghong;WU Min(Cooperative Innovation Center for Sustainable Pig Production,Huazhong Agricultural University,Wuhan 430070,China;Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou 325000,China)

机构地区：[1]华中农业大学生猪健康养殖协同创新中心,湖北武汉430070 [2]中国科学院大学温州研究院,浙江温州325000

出　　处：《中国兽医杂志》2024年第7期102-107,共6页Chinese Journal of Veterinary Medicine

基　　金：“十三五”国家重点研发计划食品安全关键技术研发项目(2017YFC1600100)。

摘　　要：细菌耐药性的迅速发展对公众健康构成了严重威胁。迫切需要新的抗生素疗法来缓解当前的抗生素危机。基于交互敏感性(CS)的抗生素组合用药可能是一种非常有前途的疗法,因为它能够有效利用现有抗生素的相互作用来针对性地控制耐药菌的发展。本文综述了细菌中CS的分子机制,以及基于CS治疗的用药策略和涉及因素,并进一步总结了当前研究的不足和未来应用的前景,已期为治疗细菌感染提供参考。The rapid development of antibiotic resistance poses a serious threat to public health.There is an urgent need for new antibiotic therapies to mitigate the current antibiotic crisis.Antibiotic combination therapy based on collateral sensitivity(CS) may be a very promising approach,as it effectively leverages the interactions between existing antibiotics to specifically control the development of resistant bacteria.This paper reviews the molecular mechanisms of CS in bacteria,CS-based therapeutic strategies,and the factors involved.It also summarizes the current research deficiencies and future application prospects,aiming to provide references for the treatment of bacterial infections.

关 键 词：耐药性 交互敏感性 用药策略 相关因素 

分 类 号：S859.79[农业科学—临床兽医学]