Immune rebalancing at the maternal-fetal interface of maternal SARS-CoV-2 infection during early pregnancy  

作　　者：Chenxiang Xi Zihui Yan Dandan Bai Yalin Zhang Beiying Wang Xiaoxiao Han Li Wu Xiaohui Shi Zhiyi Hu Ming Tang Zhongqu Su Yingdong Liu Binya Liu Jiqing Yin Hong Wang Xiaocui Li Yanping Zhang Shaorong Gao Wenqiang Liu 

机构地区：[1]Shanghai Key Laboratory of Maternal Fetal Medicine,Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital,Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology,Frontier Science Center for Stem Cell Research,School of Life Sciences and Technology,Tongji University,Shanghai 200092,China [2]Jiaxing Maternity and Child Health Care Hospital,Jiaxing 314050,China

出　　处：《Protein & Cell》2024年第6期460-473,共14页蛋白质与细胞（英文版）

基　　金：supported by the Ministry of Science and Technology of China(2022YFC2702200,2021YFA1102900);the National Natural Science Foundation of China(Grant Nos.82022027,32270909,31721003,92168205,31871448,31820103009,and 32300684);supported by the key project of the Science and Technology of Shanghai Municipality(19JC1415300 and 21JC1405500);the Shanghai Municipal Medical and Health Discipline Construction Projects(2017ZZ02015);China Postdoctoral Science Foundation(2023M732660);the Postdoctoral Fellowship Program of CPSF(GZB20230523);Shanghai Municipal Health(Grant No.20214Y0254);Shanghai Pilot Program for Basic Research,Shanghai“Medical Academy Rising Star”Young Medical Talents Program,Shanghai First Maternity and Infant Hospital“Talent Reservoir”Sailing Program and the Fundamental Research Funds for the Central Universities.

摘　　要：The current coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus(SARS-CoV-2)remains a threat to pregnant women.However,the impact of early pregnancy SARS-CoV-2 infection on the maternal-fetal interface remains poorly understood.Here,we present a comprehensive analysis of single-cell transcriptomics and metabolomics in placental samples infected with SARS-CoV-2 during early pregnancy.Compared to control placentas,SARS-CoV-2 infection elicited immune responses at the maternal-fetal interface and induced metabolic alterations in amino acid and phospholipid profiles during the initial weeks post-infection.However,subsequent immune cell activation and heightened immune tolerance in trophoblast cells established a novel dynamic equilibrium that mitigated the impact on the maternal-fetal interface.Notably,the immune response and metabolic alterations at the maternal-fetal interface exhibited a gradual decline during the second trimester.Our study underscores the adaptive immune tolerance mechanisms and establishment of immunological balance during the first two trimesters following maternal SARS-CoV-2 infection.

关 键 词：FETAL alterations PREGNANCY 

分 类 号：R714.2[医药卫生—妇产科学]