中晚期原发性肝癌患者中医药结合综合治疗的临床效果  

Clinical Effect of Traditional Chinese Medicine Combined with Comprehensive Treatment in Patients with Advanced Primary Liver Cancer

作　　者：李玫萱 姜佳呈 卫建洪 伍玉南[2] LI Meixuan;JIANG Jiacheng;WEI Jianhong;WU Yunan(The First Clinical College of Hunan University of Traditional Chinese Medicine,Changsha 410208,Hunan,China;Department of Hepatology,the First Clinical College of Hunan University of Traditional Chinese Medicine,Changsha 410007,Hunan,China)

机构地区：[1]湖南中医药大学第一临床学院,湖南长沙410208 [2]湖南中医药大学第一临床学院肝病科,湖南长沙410007

出　　处：《中国药物滥用防治杂志》2024年第5期924-927,932,共5页Chinese Journal of Drug Abuse Prevention and Treatment

基　　金：湖南省自然科学基金(编号:2021JJ30526);湖南省中医药科研基金(编号:C2023008);湖南中医药大学研究生创新课题(编号:2021CX77)。

摘　　要：目的:研究中晚期原发性肝癌患者应用中医药综合治疗的临床疗效及安全性。方法:选取2020年9月—2023年3月湖南中医药大学第一附属医院收治的中晚期原发性肝癌患者60例。根据随机数字表法将患者分为对照组和观察组,每组30例。对照组予以常规综合治疗,观察组在对照组基础上予以中医药治疗。比较两组临床疗效、不良反应、生存率及总生存期。结果:观察组治疗总有效率高于对照组,但差异无统计学意义(P>0.05);观察组疾病控制率高于对照组(P<0.05);观察组不良反应发生率低于对照组(P<0.05);靶向治疗、介入治疗、免疫治疗以及中医药治疗均能够成为延长中晚期原发性肝癌患者生存的独立因素。结论:在中晚期原发性肝癌患者临床治疗中应用中医药能够有效地降低不良反应的发生率、控制疾病的发展进程,更进一步呵护患者的生命健康安全。Objective:To study the clinical efficacy and safety of comprehensive treatment of traditional Chinese medicine in patients with advanced primary liver cancer.Methods:Sixty patients with advanced primary liver cancer admitted to the First Affiliated Hospital of Hunan University of Traditional Chinese Medicine from September 2020 to March 2023 were selected.According to the random number table method,the patients were divided into control group and observation group,with 30 patients in each group.The control group was given routine comprehensive treatment,and the observation group was treated with traditional Chinese medicine on the basis of the control group.The clinical efficacy,adverse reactions,survival rate and overall survival were compared between the two groups.Results:The total effective rate of treatment in the observation group was higher than that in the control group,but the difference was not statistically significant(P>0.05).The disease control rate of the observation group was higher than that of the control group(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Targeted therapy,interventional therapy,immunotherapy and traditional Chinese medicine treatment can be independent factors to prolong the survival of patients with advanced primary liver cancer.Conclusion:The application of traditional Chinese medicine in the clinical treatment of patients with advanced primary liver cancer can effectively reduce the incidence of adverse reactions,control the development process of the disease,and further protect the life,health and safety of patients.

关 键 词：中晚期原发性肝癌 综合治疗 中医药 不良反应 

分 类 号：R273[医药卫生—中西医结合]