中医禁食疗法对代谢综合征患者血浆致动脉硬化指数及代谢指标的影响  

Effect of traditional Chinese medicine fasting therapy on atherogenic index of plasma and metabolic indices in patients with metabolic syndrome

作　　者：王丽芳 金斌斌[1] 谢玉叶 Wang Lifang;Jin Binbin;Xie Yuye(Department of Endocrinology,Wenzhou Traditional Chinese Medicine Hospital,Wenzhou 325000,Zhejiang Province,China)

机构地区：[1]温州市中医院内分泌科,温州325000

出　　处：《中国基层医药》2024年第6期853-857,共5页Chinese Journal of Primary Medicine and Pharmacy

基　　金：浙江省市县级科技计划(2021Y0934)。

摘　　要：目的分析中医禁食疗法对代谢综合征(MS)患者血浆致动脉硬化指数(AIP)及代谢指标的影响。方法采用病例对照研究,选取温州市中医院2021年6月至2023年6月就诊的MS患者90例,根据随机数字表法将其分为两组,各45例,对照组正常饮食,观察组接受中医禁食疗法。比较两组血脂指标、AIP、胰岛素抵抗指数(HOMA-IR)、人体测量学指标、氧化应激反应指标。结果观察组治疗后低密度脂蛋白胆固醇(LDL-C)[(2.11±0.26)mmol/L]、总胆固醇(TC)[(4.31±0.26)mmol/L]、三酰甘油(TG)[(1.39±0.26)mmol/L]均低于对照组[(2.95±0.34)mmol/L、(5.24±0.33)mmol/L、(2.68±0.41)mmol/L](t=13.16、14.85、17.82,均P<0.001),观察组治疗后高密度脂蛋白胆固醇(HDL-C)[(1.18±0.09)mmol/L]高于对照组[(1.03±0.04)mmol/L](t=10.21,P<0.001)。观察组治疗后AIP(0.10±0.04)、HOMA-IR(5.12±0.42)均低于对照组[(0.28±0.10)、(5.80±0.67)](t=11.21、5.76,均P<0.001)。观察组治疗后腰围[(91.05±4.26)cm]、臀围[(98.16±5.06)cm]、内脏脂肪指数(VAI)[(3.94±0.52)]均低于对照组[(95.55±9.87)cm、(102.64±9.84)cm、(5.66±1.04)](t=2.80、2.71、9.92,均P<0.05)。观察组治疗后血清超氧化物歧化酶(SOD)水平[(101.52±13.52)U/mL]高于对照组[(80.01±6.82)U/mL](t=9.52,P<0.001),观察组治疗后血清丙二醛(MDA)水平[(4.41±0.35)nmol/L]低于对照组[(6.26±0.61)nmol/L](t=17.64,P<0.001)。结论中医禁食疗法可有效降低MS患者AIP、血脂、腰围、臀围及VAI,减轻氧化应激反应,效果显著。Objective To analyze the effect of traditional Chinese medicine fasting therapy on atherogenic index of plasma and metabolic indices in patients with metabolic syndrome.Methods A case-control study was conducted on 90 patients with metabolic syndrome who were treated at Wenzhou Traditional Chinese Medicine Hospital between June 2021 and June 2023.The patients were divided into two groups with 45 patients in each group using a random number table method.The control group was given a normal diet,while the observation group underwent traditional Chinese medicine fasting therapy.Blood lipid indexes,atherogenic index of plasma,Homeostasis Model Assessment of Insulin Resistance index,anthropometric indices,and oxidative stress response were compared between the two groups.Results After treatment,the levels of low-density lipoprotein cholesterol,total cholesterol,and triglyceride in the observation group were(2.11±0.26)mmol/L,(4.31±0.26)mmol/L,and(1.39±0.26)mmol/L,respectively.They were significantly lower than those in the control group[(2.95±0.34)mmol/L,(5.24±0.33)mmol/L,(2.68±0.41)mmol/L,t=13.16,14.85,17.82,all P<0.05].After treatment,the level of high-density lipoprotein cholesterol was significantly higher in the observation group than in the control group[(1.18±0.09)mmol/L vs.(1.03±0.04)mmol/L,t=10.21,P<0.001].After treatment,atherogenic index of plasma and Homeostasis Model Assessment of Insulin Resistance index in the observation group were(0.10±0.04)and(5.12±0.42),respectively in the observation group.They were significantly lower than those in the control group[(0.28±0.10),(5.80±0.67),t=11.21,5.76,both P<0.001].After treatment,waist circumference,hip circumference,and visceral adiposity index in the observation group were(91.05±4.26)cm,(98.16±5.06)cm,and(3.94±0.52),respectively.They were significantly lower than those in the control group[(95.55±9.87)cm,(102.64±9.84)cm,(5.66±1.04),t=2.80,2.71,9.92,all P<0.05].After treatment,the level of superoxide dismutase in the observation group was signi

关 键 词：禁食 医学 中国传统 代谢综合征X 动脉硬化 血脂异常 超氧化物歧化酶 丙二醛 

分 类 号：R259[医药卫生—中西医结合]